| http://purl.uniprot.org/citations/15078574 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15078574 | http://www.w3.org/2000/01/rdf-schema#comment | "Histamine H(3) receptors (H3Rs) were first characterized as autoreceptors modulating histamine release and synthesis via negative feedback. Acute H3R stimulation or blockade with selective agonists and antagonists suggests a role for H3R in anxiety and cognition. However, little is known about the long-term effects of H3R blockade on brain function. In the current study, mice lacking H3 receptors (H3R(-/-)) were used to investigate the role of H3R-mediated signalling in anxiety and cognition. H3R(-/-) mice showed enhanced spatial learning and memory in the Barnes maze. In addition, H3R(-/-) mice showed reduced measures of anxiety in the elevated plus and zero mazes involving exploratory behaviour and avoidable anxiety-provoking stimuli, but enhanced acoustic startle responses involving unavoidable anxiety-provoking stimuli. These behavioural alterations were associated with higher arginine vasopressin levels in the central and basolateral nuclei of the amygdala. These findings support a role for H3Rs in mediating histamine effects on spatial learning and memory and measures of anxiety."xsd:string |
| http://purl.uniprot.org/citations/15078574 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1460-9568.2004.03251.x"xsd:string |
| http://purl.uniprot.org/citations/15078574 | http://purl.uniprot.org/core/author | "Raber J."xsd:string |
| http://purl.uniprot.org/citations/15078574 | http://purl.uniprot.org/core/author | "Robertson J."xsd:string |
| http://purl.uniprot.org/citations/15078574 | http://purl.uniprot.org/core/author | "Curley J."xsd:string |
| http://purl.uniprot.org/citations/15078574 | http://purl.uniprot.org/core/author | "Rizk A."xsd:string |
| http://purl.uniprot.org/citations/15078574 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15078574 | http://purl.uniprot.org/core/name | "Eur J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/15078574 | http://purl.uniprot.org/core/pages | "1992-1996"xsd:string |
| http://purl.uniprot.org/citations/15078574 | http://purl.uniprot.org/core/title | "Anxiety and cognition in histamine H3 receptor-/- mice."xsd:string |
| http://purl.uniprot.org/citations/15078574 | http://purl.uniprot.org/core/volume | "19"xsd:string |
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