| http://purl.uniprot.org/citations/15078898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15078898 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies have indicated that the E2A gene products are required to initiate B lineage development. Here, we demonstrate that E2A(+/-) B cells that express an autoreactive B cell receptor fail to mature due in part to an inability to activate secondary immunoglobulin (Ig) light chain gene rearrangement. Both RAG1/2 gene expression and RS deletion are severely defective in E2A(+/-) mice. Additionally, we demonstrate that E2A(+/-) mice show an increase in the proportion of marginal zone B cells with a concomitant decrease in the proportion of follicular B cells. In contrast, Id3-deficient splenocytes show a decline in the proportion of marginal zone B cells. Based on these observations, we propose that E-protein activity regulates secondary Ig gene rearrangement at the immature B cell stage and contributes to cell fate determination of marginal zone B cells. Additionally, we propose a model in which E-proteins enforce the developmental checkpoint at the immature B cell stage."xsd:string |
| http://purl.uniprot.org/citations/15078898 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20031180"xsd:string |
| http://purl.uniprot.org/citations/15078898 | http://purl.uniprot.org/core/author | "Nemazee D."xsd:string |
| http://purl.uniprot.org/citations/15078898 | http://purl.uniprot.org/core/author | "Quong M.W."xsd:string |
| http://purl.uniprot.org/citations/15078898 | http://purl.uniprot.org/core/author | "Murre C."xsd:string |
| http://purl.uniprot.org/citations/15078898 | http://purl.uniprot.org/core/author | "Rivera R.R."xsd:string |
| http://purl.uniprot.org/citations/15078898 | http://purl.uniprot.org/core/author | "Martensson A."xsd:string |
| http://purl.uniprot.org/citations/15078898 | http://purl.uniprot.org/core/author | "Langerak A.W."xsd:string |
| http://purl.uniprot.org/citations/15078898 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15078898 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/15078898 | http://purl.uniprot.org/core/pages | "1101-1112"xsd:string |
| http://purl.uniprot.org/citations/15078898 | http://purl.uniprot.org/core/title | "Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2A."xsd:string |
| http://purl.uniprot.org/citations/15078898 | http://purl.uniprot.org/core/volume | "199"xsd:string |
| http://purl.uniprot.org/citations/15078898 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15078898 |
| http://purl.uniprot.org/citations/15078898 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15078898 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J011-mappedCitation-15078898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15078898 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J014-mappedCitation-15078898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15078898 |
| http://purl.uniprot.org/uniprot/#_D3Z037-mappedCitation-15078898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15078898 |
| http://purl.uniprot.org/uniprot/#_E9PWE2-mappedCitation-15078898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15078898 |
| http://purl.uniprot.org/uniprot/#_E9PWE3-mappedCitation-15078898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15078898 |
| http://purl.uniprot.org/uniprot/#_E9PWE4-mappedCitation-15078898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15078898 |
| http://purl.uniprot.org/uniprot/#_E9PWE5-mappedCitation-15078898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15078898 |
| http://purl.uniprot.org/uniprot/#_E9PVV1-mappedCitation-15078898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15078898 |
| http://purl.uniprot.org/uniprot/#_E9PVV2-mappedCitation-15078898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15078898 |