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http://purl.uniprot.org/citations/15079806http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15079806http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the correlation between the polymorphisms of apolipoprotein E(APOE), the interleukin-1 alpha (IL-1 alpha ) genes and the susceptibility to Alzheimer's disease(AD).

Methods

Association study was performed in 114 AD patients and 113 healthy elderly individuals from Chengdu, China. Polymorphisms of APOE and IL-1 alpha genes were analyzed with polymerase chain reaction-restriction fragment length polymorphism.

Results

The frequency of APOE-epsilon 4-carrying genotype in moderate to severe AD patients (28.6%) was higher than that of mild patients (18.5%) and the controls (14.2%), and the difference between moderate to severe AD group and the control group was significant (OR=2.4, 95%CI: 1.1-5.5). The frequency of epsilon 4 was also of significant difference between the group of moderate to severe dementia and the control group (OR=2.6, 95%CI: 1.3-5.3). However, no significant difference in distribution of IL-1 alpha polymorphism between AD patients and controls was observed.

Conclusion

The APOE epsilon 4 allele was associated with moderate to severe AD while no association between the IL-1 alpha gene polymorphism and AD was found."xsd:string
http://purl.uniprot.org/citations/15079806http://purl.uniprot.org/core/author"Han H.Y."xsd:string
http://purl.uniprot.org/citations/15079806http://purl.uniprot.org/core/author"Shen Y."xsd:string
http://purl.uniprot.org/citations/15079806http://purl.uniprot.org/core/author"Zhang Z.X."xsd:string
http://purl.uniprot.org/citations/15079806http://purl.uniprot.org/core/author"Liu X.H."xsd:string
http://purl.uniprot.org/citations/15079806http://purl.uniprot.org/core/author"Tang M.N."xsd:string
http://purl.uniprot.org/citations/15079806http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15079806http://purl.uniprot.org/core/name"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/15079806http://purl.uniprot.org/core/pages"176-178"xsd:string
http://purl.uniprot.org/citations/15079806http://purl.uniprot.org/core/title"[Analysis on association between the polymorphisms in apolipoprotein E, interleukin-1 alpha genes and Alzheimer's disease in Chengdu area]."xsd:string
http://purl.uniprot.org/citations/15079806http://purl.uniprot.org/core/volume"21"xsd:string
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