| http://purl.uniprot.org/citations/15081425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15081425 | http://www.w3.org/2000/01/rdf-schema#comment | "The regulator of fibroblast growth factor 2 (FGF-2) transcription (RFT) has been reported to be a transcriptional repressor of FGF-2 and induce glioma cell death by its overexpression. Here we report that RFT regulates cell cycle as well as apoptosis by a novel mechanism. RFT expressed in some glioma cell lines, U138MG and T98G, but neither in U87MG nor U251MG. Overexpressed RFT-induced apoptosis in U87MG and U138MG with functioning-type p53 but neither in U251MG nor T98G with non-functioning-type p53. Administration of FGF-2 failed to prevent RFT-induced apoptosis. Overexpression of RFT caused G1-S arrest and upregulated both the phosphorylation of p53 at Ser-15 and the expression level of p21(Waf1). Furthermore, RNAi knockdown of p53 abolished RFT-induced apoptosis in U87MG. Taken together, our results support that RFT regulates G1-S transition and apoptosis via p53/p21(Waf1) pathway."xsd:string |
| http://purl.uniprot.org/citations/15081425 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2004.03.120"xsd:string |
| http://purl.uniprot.org/citations/15081425 | http://purl.uniprot.org/core/author | "Arakawa Y."xsd:string |
| http://purl.uniprot.org/citations/15081425 | http://purl.uniprot.org/core/author | "Hashimoto N."xsd:string |
| http://purl.uniprot.org/citations/15081425 | http://purl.uniprot.org/core/author | "Kano H."xsd:string |
| http://purl.uniprot.org/citations/15081425 | http://purl.uniprot.org/core/author | "Kageyama R."xsd:string |
| http://purl.uniprot.org/citations/15081425 | http://purl.uniprot.org/core/author | "Takahashi J.A."xsd:string |
| http://purl.uniprot.org/citations/15081425 | http://purl.uniprot.org/core/author | "Nozaki K."xsd:string |
| http://purl.uniprot.org/citations/15081425 | http://purl.uniprot.org/core/author | "Takatsuka K."xsd:string |
| http://purl.uniprot.org/citations/15081425 | http://purl.uniprot.org/core/author | "Kawabata Y."xsd:string |
| http://purl.uniprot.org/citations/15081425 | http://purl.uniprot.org/core/author | "Ueba T."xsd:string |
| http://purl.uniprot.org/citations/15081425 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15081425 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/15081425 | http://purl.uniprot.org/core/pages | "902-908"xsd:string |
| http://purl.uniprot.org/citations/15081425 | http://purl.uniprot.org/core/title | "Overexpression of RFT induces G1-S arrest and apoptosis via p53/p21(Waf1) pathway in glioma cell."xsd:string |
| http://purl.uniprot.org/citations/15081425 | http://purl.uniprot.org/core/volume | "317"xsd:string |
| http://purl.uniprot.org/citations/15081425 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15081425 |
| http://purl.uniprot.org/citations/15081425 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15081425 |
| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-15081425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15081425 |
| http://purl.uniprot.org/uniprot/#_A0A087X1Q1-mappedCitation-15081425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15081425 |
| http://purl.uniprot.org/uniprot/#_A0A0C4KX50-mappedCitation-15081425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15081425 |
| http://purl.uniprot.org/uniprot/#_A0A218MJE5-mappedCitation-15081425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15081425 |
| http://purl.uniprot.org/uniprot/#_A0A087WT22-mappedCitation-15081425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15081425 |
| http://purl.uniprot.org/uniprot/#_A0A0A0U7X4-mappedCitation-15081425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15081425 |