| http://purl.uniprot.org/citations/15082179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15082179 | http://www.w3.org/2000/01/rdf-schema#comment | "The injection of formalin into the hindpaws of rats and mice is widely used as a model of inflammatory pain. The allodynia observed in this model is due in part to sensitization of spinal cord dorsal horn neurons, a form of neuroplasticity similar to long-term potentiation in the hippocampus. Ca(2+)/calmodulin-dependent kinase type IIalpha (CaMKIIalpha) is a key component of long-term potentiation. Here we report alterations in CaMKIIalpha mRNA and protein expression in spinal cord tissue from wild-type and heme oxygenase type 2 (HO-2) null mutant mice after formalin injection. Behavioral experiments demonstrated a long lived allodynia in wild-type C57Bl/6J mice after hindpaw formalin injection, but less in null mutant mice. Both CaMKIIalpha mRNA and protein expression were increased in a time-dependent manner in the spinal cords of wild-type mice after formalin injection. Confocal microscopy localized the increased expression to the superficial laminae of the spinal cord dorsal horn. In the HO-2 null mutant mice no significant change in CaMKIIalpha mRNA expression and only a small increase in protein were noted. These findings suggest that time-dependent CaMKIIalpha expression may underlie central sensitization and allodynia induced by hindpaw formalin injection, and that this process is modulated by HO-2."xsd:string |
| http://purl.uniprot.org/citations/15082179 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neulet.2004.02.050"xsd:string |
| http://purl.uniprot.org/citations/15082179 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/15082179 | http://purl.uniprot.org/core/author | "Clark J.D."xsd:string |
| http://purl.uniprot.org/citations/15082179 | http://purl.uniprot.org/core/author | "Liang D.Y."xsd:string |
| http://purl.uniprot.org/citations/15082179 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15082179 | http://purl.uniprot.org/core/name | "Neurosci Lett"xsd:string |
| http://purl.uniprot.org/citations/15082179 | http://purl.uniprot.org/core/pages | "61-64"xsd:string |
| http://purl.uniprot.org/citations/15082179 | http://purl.uniprot.org/core/title | "Formalin-induced spinal cord calcium/calmodulin-dependent protein kinase II alpha expression is modulated by heme oxygenase in mice."xsd:string |
| http://purl.uniprot.org/citations/15082179 | http://purl.uniprot.org/core/volume | "360"xsd:string |
| http://purl.uniprot.org/citations/15082179 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15082179 |
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