| http://purl.uniprot.org/citations/15082527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15082527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15082527 | http://www.w3.org/2000/01/rdf-schema#comment | "Mammalian oxygen homeostasis is dependent on the HIF family of transcription factors. The CSN subunit, CSN5, binds both the CODD of HIF-1 alpha and the pVHL tumor suppressor. High CSN5 expression generates a pVHL-independent form of CSN5 that stabilizes HIF-1 alpha aerobically by inhibiting HIF-1 alpha prolyl-564 hydroxylation. Aerobic CSN5 association with HIF-1 alpha occurs independently of the CSN holocomplex, leading to HIF-1 alpha stabilization independent of Cullin 2 deneddylation. CSN5 weakly associates with HIF-1 alpha under hypoxia, but is required for optimal hypoxia-mediated HIF-1 alpha stabilization. These results indicate that CSN5 regulates aerobic as well as hypoxic HIF-1 alpha stability by different mechanisms during oncogenesis."xsd:string |
| http://purl.uniprot.org/citations/15082527 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1180104"xsd:string |
| http://purl.uniprot.org/citations/15082527 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1180104"xsd:string |
| http://purl.uniprot.org/citations/15082527 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/15082527 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/15082527 | http://purl.uniprot.org/core/author | "Qi L."xsd:string |
| http://purl.uniprot.org/citations/15082527 | http://purl.uniprot.org/core/author | "Qi L."xsd:string |
| http://purl.uniprot.org/citations/15082527 | http://purl.uniprot.org/core/author | "Finkielstein C.V."xsd:string |
| http://purl.uniprot.org/citations/15082527 | http://purl.uniprot.org/core/author | "Finkielstein C.V."xsd:string |
| http://purl.uniprot.org/citations/15082527 | http://purl.uniprot.org/core/author | "Giaccia A.J."xsd:string |
| http://purl.uniprot.org/citations/15082527 | http://purl.uniprot.org/core/author | "Giaccia A.J."xsd:string |
| http://purl.uniprot.org/citations/15082527 | http://purl.uniprot.org/core/author | "Bemis L."xsd:string |
| http://purl.uniprot.org/citations/15082527 | http://purl.uniprot.org/core/author | "Bemis L."xsd:string |
| http://purl.uniprot.org/citations/15082527 | http://purl.uniprot.org/core/author | "Chan D.A."xsd:string |
| http://purl.uniprot.org/citations/15082527 | http://purl.uniprot.org/core/author | "Chan D.A."xsd:string |
| http://purl.uniprot.org/citations/15082527 | http://purl.uniprot.org/core/author | "Stenmark K."xsd:string |
| http://purl.uniprot.org/citations/15082527 | http://purl.uniprot.org/core/author | "Stenmark K."xsd:string |
| http://purl.uniprot.org/citations/15082527 | http://purl.uniprot.org/core/author | "Sutphin P.D."xsd:string |
| http://purl.uniprot.org/citations/15082527 | http://purl.uniprot.org/core/author | "Sutphin P.D."xsd:string |
| http://purl.uniprot.org/citations/15082527 | http://purl.uniprot.org/core/author | "Zundel W."xsd:string |
| http://purl.uniprot.org/citations/15082527 | http://purl.uniprot.org/core/author | "Zundel W."xsd:string |
| http://purl.uniprot.org/citations/15082527 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15082527 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |