| http://purl.uniprot.org/citations/15082723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15082723 | http://www.w3.org/2000/01/rdf-schema#comment | "The serine/threonine phosphatase calcineurin is an important regulator of calcium-activated intracellular responses in eukaryotic cells. In higher eukaryotes, calcium/calmodulin-mediated activation of calcineurin facilitates direct dephosphorylation and nuclear translocation of the transcription factor nuclear factor of activated T-cells (NFAT). Recently, controversy has surrounded the role of calcineurin in mediating skeletal muscle cell hypertrophy. Here we examined the ability of calcineurin-deficient mice to undergo skeletal muscle hypertrophic growth following mechanical overload (MOV) stimulation or insulin-like growth factor-1 (IGF-1) stimulation. Two distinct models of calcineurin deficiency were employed: calcineurin Abeta gene-targeted mice, which show a approximately 50% reduction in total calcineurin, and calcineurin B1-LoxP-targeted mice crossed with a myosin light chain 1f cre knock-in allele, which show a greater than 80% loss of total calcineurin only in skeletal muscle. Calcineurin Abeta-/- and calcineurin B1-LoxP(fl/fl)-MLC-cre mice show essentially no defects in muscle growth in response to IGF-1 treatment or MOV stimulation, although calcineurin Abeta-/-mice show a basal defect in total fiber number in the plantaris and a mild secondary reduction in growth, consistent with a developmental defect in myogenesis. Both groups of gene-targeted mice show normal increases in Akt activation following MOV or IGF-1 stimulation. However, overload-mediated fiber-type switching was dramatically impaired in calcineurin B1-LoxP(fl/fl)-MLC-cre mice. NFAT-luciferase reporter transgenic mice failed to show a correlation between IGF-1- or MOV-induced hypertrophy and calcineurin-NFAT-dependent signaling in vivo. We conclude that calcineurin expression is important during myogenesis and fiber-type switching, but not for muscle growth in response to hypertrophic stimuli."xsd:string |
| http://purl.uniprot.org/citations/15082723 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m313800200"xsd:string |
| http://purl.uniprot.org/citations/15082723 | http://purl.uniprot.org/core/author | "Crabtree G.R."xsd:string |
| http://purl.uniprot.org/citations/15082723 | http://purl.uniprot.org/core/author | "Molkentin J.D."xsd:string |
| http://purl.uniprot.org/citations/15082723 | http://purl.uniprot.org/core/author | "Yutzey K.E."xsd:string |
| http://purl.uniprot.org/citations/15082723 | http://purl.uniprot.org/core/author | "Wilkins B.J."xsd:string |
| http://purl.uniprot.org/citations/15082723 | http://purl.uniprot.org/core/author | "Neilson J.R."xsd:string |
| http://purl.uniprot.org/citations/15082723 | http://purl.uniprot.org/core/author | "Bueno O.F."xsd:string |
| http://purl.uniprot.org/citations/15082723 | http://purl.uniprot.org/core/author | "Millay D.P."xsd:string |
| http://purl.uniprot.org/citations/15082723 | http://purl.uniprot.org/core/author | "Liberatore C.M."xsd:string |
| http://purl.uniprot.org/citations/15082723 | http://purl.uniprot.org/core/author | "Parsons S.A."xsd:string |
| http://purl.uniprot.org/citations/15082723 | http://purl.uniprot.org/core/author | "Tsika G.L."xsd:string |
| http://purl.uniprot.org/citations/15082723 | http://purl.uniprot.org/core/author | "Tsika R.W."xsd:string |
| http://purl.uniprot.org/citations/15082723 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15082723 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15082723 | http://purl.uniprot.org/core/pages | "26192-26200"xsd:string |
| http://purl.uniprot.org/citations/15082723 | http://purl.uniprot.org/core/title | "Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy."xsd:string |
| http://purl.uniprot.org/citations/15082723 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/15082723 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15082723 |
| http://purl.uniprot.org/citations/15082723 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15082723 |
| http://purl.uniprot.org/uniprot/#_A0A087WRZ7-mappedCitation-15082723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15082723 |
| http://purl.uniprot.org/uniprot/#_E0CZ30-mappedCitation-15082723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15082723 |
| http://purl.uniprot.org/uniprot/#_E0CZ78-mappedCitation-15082723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15082723 |
| http://purl.uniprot.org/uniprot/#_E9Q6P2-mappedCitation-15082723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15082723 |