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Objectives

The purpose of this study was to investigate whether the urokinase gene 3'-UTR C/T polymorphism is a marker of susceptibility to or severity of rheumatoid arthritis (RA) in Chinese patients.

Methods

A total of 145 RA patients and 134 healthy control subjects were enrolled in this study. We identified the C/T polymorphism of the urokinase gene, which is mapped on the 3'-untranslated region (3'-UTR) on chromosome 10 by polymerase chain reaction (PCR).

Results

There were significant differences in the distribution of the urokinase gene 3'-UTR C/T polymorphism frequency between RA patients and subjects in the control group. However, we did not detect an, association between the urokinase gene 3'-UTR C/T polymorphism and rheumatoid factor (RF), extraarticular involvement or bone erosion in RA patients.

Conclusion

The urokinase gene 3'-UTR "T" allele was associated with RA in Chinese patients in Taiwan."xsd:string
http://purl.uniprot.org/citations/15083890http://purl.uniprot.org/core/author"Tsai C.H."xsd:string
http://purl.uniprot.org/citations/15083890http://purl.uniprot.org/core/author"Chen C.L."xsd:string
http://purl.uniprot.org/citations/15083890http://purl.uniprot.org/core/author"Huang C.M."xsd:string
http://purl.uniprot.org/citations/15083890http://purl.uniprot.org/core/author"Tsai J.J."xsd:string
http://purl.uniprot.org/citations/15083890http://purl.uniprot.org/core/author"Tsai F.J."xsd:string
http://purl.uniprot.org/citations/15083890http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15083890http://purl.uniprot.org/core/name"Clin Exp Rheumatol"xsd:string
http://purl.uniprot.org/citations/15083890http://purl.uniprot.org/core/pages"219-222"xsd:string
http://purl.uniprot.org/citations/15083890http://purl.uniprot.org/core/title"Association between urokinase gene 3'-UTR T/C polymorphism and Chinese patients with rheumatoid arthritis in Taiwan."xsd:string
http://purl.uniprot.org/citations/15083890http://purl.uniprot.org/core/volume"22"xsd:string
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