| http://purl.uniprot.org/citations/15084461 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15084461 | http://www.w3.org/2000/01/rdf-schema#comment | "In response to the environment, the nematode C. elegans must choose between arrest at a long-lived alternate third larval stage, the dauer diapause, or reproductive development. This decision may ultimately be mediated by daf-9, a cytochrome P450 related to steroidogenic hydroxylases and its cognate nuclear receptor daf-12, implying organism-wide coordination by lipophilic hormones. Accordingly, here we show that daf-9(+) works cell non-autonomously to bypass diapause, and promote gonadal outgrowth. Among daf-9-expressing cells, the hypodermis is most visibly regulated by environmental inputs, including dietary cholesterol. On in reproductive growth, off in dauer, hypodermal daf-9 expression is strictly daf-12 dependent, suggesting feedback regulation. Expressing daf-9 constitutively in hypodermis rescues dauer phenotypes of daf-9, as well as insulin/IGF receptor and TGFbeta mutants, revealing that daf-9 is an important downstream point of control within the dauer circuits. This study illuminates how endocrine networks integrate environmental cues and transduce them into adaptive life history choices."xsd:string |
| http://purl.uniprot.org/citations/15084461 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.01068"xsd:string |
| http://purl.uniprot.org/citations/15084461 | http://purl.uniprot.org/core/author | "Antebi A."xsd:string |
| http://purl.uniprot.org/citations/15084461 | http://purl.uniprot.org/core/author | "Gerisch B."xsd:string |
| http://purl.uniprot.org/citations/15084461 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15084461 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/15084461 | http://purl.uniprot.org/core/pages | "1765-1776"xsd:string |
| http://purl.uniprot.org/citations/15084461 | http://purl.uniprot.org/core/title | "Hormonal signals produced by DAF-9/cytochrome P450 regulate C. elegans dauer diapause in response to environmental cues."xsd:string |
| http://purl.uniprot.org/citations/15084461 | http://purl.uniprot.org/core/volume | "131"xsd:string |
| http://purl.uniprot.org/citations/15084461 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15084461 |
| http://purl.uniprot.org/citations/15084461 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15084461 |
| http://purl.uniprot.org/uniprot/#_A0A5E4M3J0-mappedCitation-15084461 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15084461 |
| http://purl.uniprot.org/uniprot/#_H2KYS3-mappedCitation-15084461 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15084461 |
| http://purl.uniprot.org/uniprot/H2KYS3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15084461 |
| http://purl.uniprot.org/uniprot/A0A5E4M3J0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15084461 |