| http://purl.uniprot.org/citations/15084602 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15084602 | http://www.w3.org/2000/01/rdf-schema#comment | "It is widely thought that myogenin is one of the earliest detectable markers of skeletal muscle differentiation. Here we show that, during human myoblast differentiation, an inward rectifier K(+) channel (Kir2.1) and its associated hyperpolarization trigger expression and activity of the myogenic transcription factors, myogenin and myocyte enhancer factor-2 (MEF2). Furthermore, Kir2.1 current precedes and is required for the developmental increase in expression/activity of myogenin and MEF2. Drugs or antisense reducing Kir2.1 current diminished or suppressed fusion as well as expression/activity of myogenin and MEF2. In contrast, LY294002, an inhibitor of phosphatidylinositol 3-kinase (a pathway controlling initiation of the myogenic program) that inhibited both myogenin/MEF2 expression and fusion, did not affect Kir2.1 current. This non-blockade by LY294002 indicates that Kir2.1 acts upstream of myogenin and MEF2. We propose that Kir2.1 channel activation is a required key early event that initiates myogenesis by turning on myogenin and MEF2 transcription factors via a hyperpolarization-activated Ca(2+)-dependent pathway."xsd:string |
| http://purl.uniprot.org/citations/15084602 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m313932200"xsd:string |
| http://purl.uniprot.org/citations/15084602 | http://purl.uniprot.org/core/author | "Konig S."xsd:string |
| http://purl.uniprot.org/citations/15084602 | http://purl.uniprot.org/core/author | "Arnaudeau S."xsd:string |
| http://purl.uniprot.org/citations/15084602 | http://purl.uniprot.org/core/author | "Bader C.R."xsd:string |
| http://purl.uniprot.org/citations/15084602 | http://purl.uniprot.org/core/author | "Bernheim L."xsd:string |
| http://purl.uniprot.org/citations/15084602 | http://purl.uniprot.org/core/author | "Potter G."xsd:string |
| http://purl.uniprot.org/citations/15084602 | http://purl.uniprot.org/core/author | "Hinard V."xsd:string |
| http://purl.uniprot.org/citations/15084602 | http://purl.uniprot.org/core/author | "Holzer N."xsd:string |
| http://purl.uniprot.org/citations/15084602 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15084602 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15084602 | http://purl.uniprot.org/core/pages | "28187-28196"xsd:string |
| http://purl.uniprot.org/citations/15084602 | http://purl.uniprot.org/core/title | "Membrane hyperpolarization triggers myogenin and myocyte enhancer factor-2 expression during human myoblast differentiation."xsd:string |
| http://purl.uniprot.org/citations/15084602 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/15084602 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15084602 |
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