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http://purl.uniprot.org/citations/15087412http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15087412http://www.w3.org/2000/01/rdf-schema#comment"Inflammation has been implicated as an etiological factor in several human cancers. Growing evidence suggests that chronic inflammation may also play a role in the etiology of prostate cancer. Considering that genetic susceptibility is a major risk factor for this disease, we hypothesize that sequence variants in genes that regulate inflammation may modify individual susceptibility to prostate cancer. The lipopolysaccharide receptor Toll-like receptor 4 (TLR4) is a central player in the signaling pathways of the innate immune response to infection by Gram-negative bacteria and is an important candidate inflammatory gene. We performed a systematic genetic analysis of TLR4 sequence variants by evaluating eight single-nucleotide polymorphisms that span the entire gene among 1383 newly diagnosed prostate cancer patients and 780 age- and residence-matched controls in Sweden. We found an association between a sequence variant (11381G/C) in the 3'-untranslated region of the TLR4 gene and prostate cancer risk. The frequency of the variant genotypes (CG or CC) was significantly higher in the patients (24.1%) than in the controls (19.7%; P = 0.02). The frequency of risk genotypes among patients diagnosed before the age of 65 years was even higher (26.3%). Compared with men who had the wild-type genotype of this single-nucleotide polymorphism (GG), those with GC or CC genotypes had a 26% increased risk for prostate cancer (odds ratio, 1.26; 95% confidence interval, 1.01-1.57) and 39% increased risk increased risk for early onset prostate cancer (before age 65 years; odds ratio, 1.39; 95% confidence interval, 1.02-1.91). The risk attributable to this variant for prostate cancer in Sweden was estimated to be 4.9%. Although the biological mechanism of the observed association remains to be elucidated, our finding supports a role for a bacteria-associated response pathway, possibly acting via inflammation, in the development of prostate cancer."xsd:string
http://purl.uniprot.org/citations/15087412http://purl.org/dc/terms/identifier"doi:10.1158/0008-5472.can-03-3280"xsd:string
http://purl.uniprot.org/citations/15087412http://purl.uniprot.org/core/author"Li L."xsd:string
http://purl.uniprot.org/citations/15087412http://purl.uniprot.org/core/author"Li G."xsd:string
http://purl.uniprot.org/citations/15087412http://purl.uniprot.org/core/author"Chang B."xsd:string
http://purl.uniprot.org/citations/15087412http://purl.uniprot.org/core/author"Xu J."xsd:string
http://purl.uniprot.org/citations/15087412http://purl.uniprot.org/core/author"Isaacs W.B."xsd:string
http://purl.uniprot.org/citations/15087412http://purl.uniprot.org/core/author"Gronberg H."xsd:string
http://purl.uniprot.org/citations/15087412http://purl.uniprot.org/core/author"Zheng S.L."xsd:string
http://purl.uniprot.org/citations/15087412http://purl.uniprot.org/core/author"Meyers D.A."xsd:string
http://purl.uniprot.org/citations/15087412http://purl.uniprot.org/core/author"Turner A.R."xsd:string
http://purl.uniprot.org/citations/15087412http://purl.uniprot.org/core/author"Adami H.O."xsd:string
http://purl.uniprot.org/citations/15087412http://purl.uniprot.org/core/author"Adams T.S."xsd:string
http://purl.uniprot.org/citations/15087412http://purl.uniprot.org/core/author"Augustsson-Balter K."xsd:string
http://purl.uniprot.org/citations/15087412http://purl.uniprot.org/core/author"Bensen J."xsd:string
http://purl.uniprot.org/citations/15087412http://purl.uniprot.org/core/author"Hedelin M."xsd:string
http://purl.uniprot.org/citations/15087412http://purl.uniprot.org/core/author"Johnasson J.E."xsd:string
http://purl.uniprot.org/citations/15087412http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15087412http://purl.uniprot.org/core/name"Cancer Res"xsd:string
http://purl.uniprot.org/citations/15087412http://purl.uniprot.org/core/pages"2918-2922"xsd:string
http://purl.uniprot.org/citations/15087412http://purl.uniprot.org/core/title"Sequence variants of toll-like receptor 4 are associated with prostate cancer risk: results from the CAncer Prostate in Sweden Study."xsd:string
http://purl.uniprot.org/citations/15087412http://purl.uniprot.org/core/volume"64"xsd:string
http://purl.uniprot.org/citations/15087412http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15087412
http://purl.uniprot.org/citations/15087412http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15087412
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