| http://purl.uniprot.org/citations/15090455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15090455 | http://www.w3.org/2000/01/rdf-schema#comment | "Single nucleotide polymorphisms (SNPs) of the NOD2/CARD15 gene resulting in a diminished nuclear factor-kappaB (NF-kappaB) response to bacterial cell wall products have been associated with an increased incidence of Crohn disease. To assess a possible contribution of NOD2/CARD15 mutations to graft-versus-host disease (GvHD) and complications following allogeneic stem cell transplantation, we retrospectively typed DNA from donor/recipient pairs in 169 consecutive patients receiving transplants from related or unrelated donors. Mutated alleles were observed in 21% of patients and in 14% of donors. Cumulative incidence of 1-year, transplant-related mortality rose from 20% in donor/recipient pairs without mutated SNPs to 49% in pairs with recipient mutations (P =.03) and 59% in pairs with donor mutations (P <.005), and was highest in 12 pairs with mutated alleles in both donor and recipients (83%; P <.001). Similar associations were observed for severe overall and severe gastrointestinal GvHD. The impact of NOD2/CARD15 mutations was more prominent for HLA-identical sibling transplantations but was also observed in unrelated donor transplantation. Mutations proved to be independent risk factors for transplant-related mortality. Our findings indicate a major role of monocyte/macrophage dysfunction in the pathophysiology of GvHD and strongly suggest a future risk assessment or even donor selection through NOD2/CARD15 typing."xsd:string |
| http://purl.uniprot.org/citations/15090455 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2003-10-3543"xsd:string |
| http://purl.uniprot.org/citations/15090455 | http://purl.uniprot.org/core/author | "Hahn J."xsd:string |
| http://purl.uniprot.org/citations/15090455 | http://purl.uniprot.org/core/author | "Andreesen R."xsd:string |
| http://purl.uniprot.org/citations/15090455 | http://purl.uniprot.org/core/author | "Holler E."xsd:string |
| http://purl.uniprot.org/citations/15090455 | http://purl.uniprot.org/core/author | "Rogler G."xsd:string |
| http://purl.uniprot.org/citations/15090455 | http://purl.uniprot.org/core/author | "Eissner G."xsd:string |
| http://purl.uniprot.org/citations/15090455 | http://purl.uniprot.org/core/author | "Herfarth H."xsd:string |
| http://purl.uniprot.org/citations/15090455 | http://purl.uniprot.org/core/author | "Scholmerich J."xsd:string |
| http://purl.uniprot.org/citations/15090455 | http://purl.uniprot.org/core/author | "Wild P.J."xsd:string |
| http://purl.uniprot.org/citations/15090455 | http://purl.uniprot.org/core/author | "Brenmoehl J."xsd:string |
| http://purl.uniprot.org/citations/15090455 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15090455 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/15090455 | http://purl.uniprot.org/core/pages | "889-894"xsd:string |
| http://purl.uniprot.org/citations/15090455 | http://purl.uniprot.org/core/title | "Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation."xsd:string |
| http://purl.uniprot.org/citations/15090455 | http://purl.uniprot.org/core/volume | "104"xsd:string |
| http://purl.uniprot.org/citations/15090455 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15090455 |
| http://purl.uniprot.org/citations/15090455 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15090455 |
| http://purl.uniprot.org/uniprot/#_D9N2T7-mappedCitation-15090455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15090455 |
| http://purl.uniprot.org/uniprot/#_A3FA72-mappedCitation-15090455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15090455 |
| http://purl.uniprot.org/uniprot/#_A0A286YF65-mappedCitation-15090455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15090455 |
| http://purl.uniprot.org/uniprot/#_A0A3S6A229-mappedCitation-15090455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15090455 |
| http://purl.uniprot.org/uniprot/#_A0A386TXE7-mappedCitation-15090455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15090455 |
| http://purl.uniprot.org/uniprot/#_B5B2Z5-mappedCitation-15090455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15090455 |