| http://purl.uniprot.org/citations/15094785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15094785 | http://www.w3.org/2000/01/rdf-schema#comment | "Association/linkage between dopamine D4 receptor (DRD4) polymorphisms and attention-deficit/hyperactivity disorder (ADHD) has been suggested by case-control- and nuclear-family-based studies. Here, we present a candidate gene analysis for DRD4 using 14 extended and multigenerational families segregating ADHD derived from the 'Paisa' community of Antioquia, Colombia, a genetic isolate. Two DRD4 polymorphisms (a 120 bp tandem duplication at the promoter and a 48 bp-VNTR at exon 3), reported associated to ADHD, were genotyped. Parametric and non-parametric linkage analyses, and a family-based association test (FBAT), the pedigree disequilibrium test (PDT), were applied to search for evidence of association/linkage. Two-point LOD scores were significantly negative, with values ranging from -3.21 (P=0.011158) to -7.66 (P=0.000091 at theta=0). Non-parametrical analysis resulted in nonsignificant evidence for linkage. The PDT showed a moderate trend toward significance of association/linkage between the 7-repeat (7R) allele at the 48 bp VNTR and ADHD (P=0.0578). Furthermore, the haplotype analysis shows a significant association/linkage of the 7R-240 bp haplotype (P=0.0467) with ADHD. Results suggest that either a moderate DRD4 genetic effect, or linkage disequilibrium of DRD4 with an ADHD disease locus in the vicinity or the linkage to a phenotypic component of the ADHD spectrum could be underlying this association/linkage. These results provide further evidence for the association of ADHD to genetic variation in or near to DRD4 and replicate the previously reported association between ADHD and the 7R allele."xsd:string |
| http://purl.uniprot.org/citations/15094785 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.mp.4001396"xsd:string |
| http://purl.uniprot.org/citations/15094785 | http://purl.uniprot.org/core/author | "Arcos-Burgos M."xsd:string |
| http://purl.uniprot.org/citations/15094785 | http://purl.uniprot.org/core/author | "Muenke M."xsd:string |
| http://purl.uniprot.org/citations/15094785 | http://purl.uniprot.org/core/author | "Berg K."xsd:string |
| http://purl.uniprot.org/citations/15094785 | http://purl.uniprot.org/core/author | "Castellanos F.X."xsd:string |
| http://purl.uniprot.org/citations/15094785 | http://purl.uniprot.org/core/author | "Bailey-Wilson J."xsd:string |
| http://purl.uniprot.org/citations/15094785 | http://purl.uniprot.org/core/author | "Pineda D."xsd:string |
| http://purl.uniprot.org/citations/15094785 | http://purl.uniprot.org/core/author | "Rapoport J.L."xsd:string |
| http://purl.uniprot.org/citations/15094785 | http://purl.uniprot.org/core/author | "Lopera F."xsd:string |
| http://purl.uniprot.org/citations/15094785 | http://purl.uniprot.org/core/author | "Konecki D."xsd:string |
| http://purl.uniprot.org/citations/15094785 | http://purl.uniprot.org/core/author | "Palacio J.D."xsd:string |
| http://purl.uniprot.org/citations/15094785 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15094785 | http://purl.uniprot.org/core/name | "Mol Psychiatry"xsd:string |
| http://purl.uniprot.org/citations/15094785 | http://purl.uniprot.org/core/pages | "252-259"xsd:string |
| http://purl.uniprot.org/citations/15094785 | http://purl.uniprot.org/core/title | "Pedigree disequilibrium test (PDT) replicates association and linkage between DRD4 and ADHD in multigenerational and extended pedigrees from a genetic isolate."xsd:string |
| http://purl.uniprot.org/citations/15094785 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/15094785 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15094785 |
| http://purl.uniprot.org/citations/15094785 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15094785 |
| http://purl.uniprot.org/uniprot/#_Q99586-mappedCitation-15094785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15094785 |
| http://purl.uniprot.org/uniprot/#_Q99587-mappedCitation-15094785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15094785 |
| http://purl.uniprot.org/uniprot/#_Q16303-mappedCitation-15094785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15094785 |
| http://purl.uniprot.org/uniprot/#_K9MAU8-mappedCitation-15094785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15094785 |
| http://purl.uniprot.org/uniprot/#_Q76E76-mappedCitation-15094785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15094785 |