| http://purl.uniprot.org/citations/15099528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15099528 | http://www.w3.org/2000/01/rdf-schema#comment | "Histamine modulates immune responses. There are at least two ways histamine might be supplied: one is its release from cells that pool pre-formed histamine and the other is its de novo formation via induction of histidine decarboxylase (HDC). Lipopolysaccharide (LPS) and the proinflammatory cytokine interleukin (IL)-1 induce a marked elevation of HDC activity in various tissues or organs. To examine the contribution of mast cells to HDC induction in mice given LPS or IL-1, we examined the effects of LPS and IL-1 on HDC activity and/or histamine content in various organs (liver, lung, spleen or bone marrow) in mast cell-deficient mice (W/Wv), their normal littermates (+/+) and BALB/c mice deficient in IL-1alpha, IL-1beta and tumor necrosis factor (TNF)-alpha (IL-1alpha beta/TNFalphaKO mice). In non-stimulated mice, the histamine in the lung and spleen was contained largely within mast cells. The LPS-stimulated increase in HDC activity in a given organ was similar between +/+ and W/W(v) mice, and between IL-1alpha beta/TNFalphaKO BALB/c and control BALB/c mice, and led to increases in histamine. In W/Wv and +/+ mice, IL-1alpha also elevated HDC activity. These results suggest that (i) in liver, lung and spleen, either the major cells supplying histamine via HDC induction in response to LPS and IL-1 are not mast cells, or mast cells are not a prerequisite for the induction of HDC; (ii) the cells in which HDC is induced by LPS and IL-1 are similar or identical in a given organ; and (iii) neither IL-1 nor TNF-alpha is a prerequisite for the induction of HDC by LPS."xsd:string |
| http://purl.uniprot.org/citations/15099528 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.intimp.2003.10.011"xsd:string |
| http://purl.uniprot.org/citations/15099528 | http://purl.uniprot.org/core/author | "Endo Y."xsd:string |
| http://purl.uniprot.org/citations/15099528 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/15099528 | http://purl.uniprot.org/core/author | "Yoshida A."xsd:string |
| http://purl.uniprot.org/citations/15099528 | http://purl.uniprot.org/core/author | "Iwakura Y."xsd:string |
| http://purl.uniprot.org/citations/15099528 | http://purl.uniprot.org/core/author | "Sasano T."xsd:string |
| http://purl.uniprot.org/citations/15099528 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15099528 | http://purl.uniprot.org/core/name | "Int Immunopharmacol"xsd:string |
| http://purl.uniprot.org/citations/15099528 | http://purl.uniprot.org/core/pages | "513-520"xsd:string |
| http://purl.uniprot.org/citations/15099528 | http://purl.uniprot.org/core/title | "Histamine production via mast cell-independent induction of histidine decarboxylase in response to lipopolysaccharide and interleukin-1."xsd:string |
| http://purl.uniprot.org/citations/15099528 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/15099528 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15099528 |
| http://purl.uniprot.org/citations/15099528 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15099528 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J210-mappedCitation-15099528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15099528 |
| http://purl.uniprot.org/uniprot/#_A0A0U5J4W4-mappedCitation-15099528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15099528 |
| http://purl.uniprot.org/uniprot/#_Q7TMW5-mappedCitation-15099528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15099528 |
| http://purl.uniprot.org/uniprot/#_Q3TI17-mappedCitation-15099528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15099528 |
| http://purl.uniprot.org/uniprot/#_Q3U0Y6-mappedCitation-15099528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15099528 |
| http://purl.uniprot.org/uniprot/#_Q3U593-mappedCitation-15099528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15099528 |
| http://purl.uniprot.org/uniprot/#_Q62161-mappedCitation-15099528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15099528 |
| http://purl.uniprot.org/uniprot/#_P01582-mappedCitation-15099528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15099528 |
| http://purl.uniprot.org/uniprot/#_P10749-mappedCitation-15099528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15099528 |
| http://purl.uniprot.org/uniprot/#_P06804-mappedCitation-15099528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15099528 |