| http://purl.uniprot.org/citations/15100151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15100151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15100151 | http://www.w3.org/2000/01/rdf-schema#comment | "The triggering receptors expressed on myeloid cells (TREMs) have drawn considerable attention due to their ability to activate multiple cell types within the innate immune system, including neutrophils, monocyte/macrophages, and dendritic cells, via their association with DAP12. TLT-1 (TREM-like transcript-1) lies within the TREM gene cluster and contains the characteristic single V-set immunoglobulin (Ig) domain of the family, but its longer cytoplasmic tail is composed of both a proline-rich region and an immune receptor tyrosine-based inhibitory motif, the latter known to be used for interactions with protein tyrosine phosphatases. Here we report that TLT-1 is expressed exclusively in platelets and megakaryocytes (MKs) and that TLT-1 expression is up-regulated dramatically upon platelet activation. Consistent with this observation, confocal microscopy demonstrates that TLT-1 is prepackaged, along with CD62P, into both MK and platelet alpha-granules. Differences in thrombin-induced redistribution of CD62P and TLT-1 indicate that TLT-1 is not simply cargo of alpha-granules but may instead regulate granule construction or dispersal. Together these data show that that TLT-1 does not function to inhibit members of the TREM family but instead may play a role in maintaining vascular hemostasis and regulating coagulation and inflammation at sites of injury."xsd:string |
| http://purl.uniprot.org/citations/15100151 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2004-01-0315"xsd:string |
| http://purl.uniprot.org/citations/15100151 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2004-01-0315"xsd:string |
| http://purl.uniprot.org/citations/15100151 | http://purl.uniprot.org/core/author | "Cho E.H."xsd:string |
| http://purl.uniprot.org/citations/15100151 | http://purl.uniprot.org/core/author | "Cho E.H."xsd:string |
| http://purl.uniprot.org/citations/15100151 | http://purl.uniprot.org/core/author | "McVicar D.W."xsd:string |
| http://purl.uniprot.org/citations/15100151 | http://purl.uniprot.org/core/author | "McVicar D.W."xsd:string |
| http://purl.uniprot.org/citations/15100151 | http://purl.uniprot.org/core/author | "Washington A.V."xsd:string |
| http://purl.uniprot.org/citations/15100151 | http://purl.uniprot.org/core/author | "Washington A.V."xsd:string |
| http://purl.uniprot.org/citations/15100151 | http://purl.uniprot.org/core/author | "Disipio T."xsd:string |
| http://purl.uniprot.org/citations/15100151 | http://purl.uniprot.org/core/author | "Disipio T."xsd:string |
| http://purl.uniprot.org/citations/15100151 | http://purl.uniprot.org/core/author | "Feltz R."xsd:string |
| http://purl.uniprot.org/citations/15100151 | http://purl.uniprot.org/core/author | "Feltz R."xsd:string |
| http://purl.uniprot.org/citations/15100151 | http://purl.uniprot.org/core/author | "Quigley L."xsd:string |
| http://purl.uniprot.org/citations/15100151 | http://purl.uniprot.org/core/author | "Quigley L."xsd:string |
| http://purl.uniprot.org/citations/15100151 | http://purl.uniprot.org/core/author | "Schubert R.L."xsd:string |
| http://purl.uniprot.org/citations/15100151 | http://purl.uniprot.org/core/author | "Schubert R.L."xsd:string |
| http://purl.uniprot.org/citations/15100151 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15100151 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15100151 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/15100151 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/15100151 | http://purl.uniprot.org/core/pages | "1042-1047"xsd:string |
| http://purl.uniprot.org/citations/15100151 | http://purl.uniprot.org/core/pages | "1042-1047"xsd:string |