| http://purl.uniprot.org/citations/15100278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15100278 | http://www.w3.org/2000/01/rdf-schema#comment | "One of the earliest functional responses of T lymphocytes to extracellular signals that activate the Ag-specific CD3/TCR complex is a rapid, but reversible, increase in the functional activity of integrin adhesion receptors. Previous studies have implicated the tyrosine kinase zeta-associated protein of 70 kDa (ZAP-70) and the lipid kinase phosphatidylinositol 3-kinase, in the activation of beta(1) integrins by the CD3/TCR complex. In this report, we use human ZAP-70-deficient Jurkat T cells to demonstrate that the kinase activity of ZAP-70 is required for CD3/TCR-mediated increases in beta(1) integrin-mediated adhesion and activation of phosphatidylinositol 3-kinase. A tyrosine to phenylalanine substitution at position 315 in the interdomain B of ZAP-70 inhibits these responses, whereas a similar substitution at position 292 enhances these downstream signals. These mutations in the ZAP-70 interdomain B region also specifically affect CD3/TCR-mediated tyrosine phosphorylation of residues 171 and 191 in the cytoplasmic domain of the linker for activation of T cells (LAT) adapter protein. CD3/TCR signaling to beta(1) integrins is defective in LAT-deficient Jurkat T cells, and can be restored with expression of wild-type LAT. Mutant LAT constructs with tyrosine to phenylalanine substitutions at position 171 and/or position 191 do not restore CD3/TCR-mediated activation of beta(1) integrins in LAT-deficient T cells. Thus, these studies demonstrate that the interdomain B region of ZAP-70 regulates beta(1) integrin activation by the CD3/TCR via control of tyrosine phosphorylation of tyrosine residues 171 and 191 in the LAT cytoplasmic domain."xsd:string |
| http://purl.uniprot.org/citations/15100278 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.172.9.5379"xsd:string |
| http://purl.uniprot.org/citations/15100278 | http://purl.uniprot.org/core/author | "Goda S."xsd:string |
| http://purl.uniprot.org/citations/15100278 | http://purl.uniprot.org/core/author | "Shimizu Y."xsd:string |
| http://purl.uniprot.org/citations/15100278 | http://purl.uniprot.org/core/author | "Felthauser A."xsd:string |
| http://purl.uniprot.org/citations/15100278 | http://purl.uniprot.org/core/author | "Woods M.L."xsd:string |
| http://purl.uniprot.org/citations/15100278 | http://purl.uniprot.org/core/author | "Quale A.C."xsd:string |
| http://purl.uniprot.org/citations/15100278 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15100278 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15100278 | http://purl.uniprot.org/core/pages | "5379-5387"xsd:string |
| http://purl.uniprot.org/citations/15100278 | http://purl.uniprot.org/core/title | "Control of TCR-mediated activation of beta 1 integrins by the ZAP-70 tyrosine kinase interdomain B region and the linker for activation of T cells adapter protein."xsd:string |
| http://purl.uniprot.org/citations/15100278 | http://purl.uniprot.org/core/volume | "172"xsd:string |
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