| http://purl.uniprot.org/citations/15101424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15101424 | http://www.w3.org/2000/01/rdf-schema#comment | "Life-history trade-offs prevent different components of fitness from being maximized simultaneously. Although the existence of trade-offs has been clearly demonstrated, the 'classical' mechanism of adaptive resource allocation that should underlie them has recently received criticism. In this study, we explore the molecular mechanisms of life-history trade-offs by applying a quantitative genomic approach. Analysis of global gene expression in Drosophila melanogaster revealed 34 genes whose expression coincided with the genetic trade-off between larval survival and adult size. The joint expression of these candidate 'trade-off' genes explained 86.3% of the trade-off. Fourteen of these genes have known functions which suggest that the larval survival-adult size trade-off could be the result of resource allocation at the organismal level, but at the level of cellular metabolism the trade-off would reduce to a shift between energy metabolism versus protein biosynthesis, regulated by the RAS signalling pathway."xsd:string |
| http://purl.uniprot.org/citations/15101424 | http://purl.org/dc/terms/identifier | "doi:10.1098/rsbl.2003.0091"xsd:string |
| http://purl.uniprot.org/citations/15101424 | http://purl.uniprot.org/core/author | "Bochdanovits Z."xsd:string |
| http://purl.uniprot.org/citations/15101424 | http://purl.uniprot.org/core/author | "de Jong G."xsd:string |
| http://purl.uniprot.org/citations/15101424 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15101424 | http://purl.uniprot.org/core/name | "Proc Biol Sci 271 Suppl"xsd:string |
| http://purl.uniprot.org/citations/15101424 | http://purl.uniprot.org/core/pages | "S75-8"xsd:string |
| http://purl.uniprot.org/citations/15101424 | http://purl.uniprot.org/core/title | "Antagonistic pleiotropy for life-history traits at the gene expression level."xsd:string |
| http://purl.uniprot.org/citations/15101424 | http://purl.uniprot.org/core/volume | "3"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KGK9-mappedCitation-15101424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15101424 |
| http://purl.uniprot.org/uniprot/#_A8JQZ7-mappedCitation-15101424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15101424 |
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