| http://purl.uniprot.org/citations/15102084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15102084 | http://www.w3.org/2000/01/rdf-schema#comment | "Human airway trypsin-like protease (HAT), a novel serine protease in the airways, enhances cell growth and IL-8 production. The expression and role of HAT in the skin however, is unknown. Immunofluorescence staining and reverse transcription (RT)-PCR were done to know HAT production in normal and psoriatic tissues and keratinocyte cell lines. Cell growth and/or IL-8 release analyses were made by bromo-deoxyuridine (BrdU) uptake and ELISA. Psoriatic epidermis showed more extensive immunofluorescence expression of HAT, and less extensive expression of protease-activated receptor (PAR)-2. RT-PCR demonstrated a higher HAT and a lesser PAR-2 mRNA expressions in psoriatic epidermis. Normal keratinocyte and epidermoid carcinoma cell lines expressed HAT and PAR-2 mRNA, and immortalized keratinocytes (HaCaT) expressed PAR-2, but not HAT mRNA. PAR-2 was detected along the keratinocyte surface in culture and became invisible upon HAT stimulation, suggesting a process of its internalization. HAT or PAR-2 activating peptide did not enhance BrdU uptake, but induced an IL-8 release. Treatment with HAT and IL-1beta synergistically increased the effect of IL-8 release. Inhibition of PAR-2 resulted in a decreased HAT-induced IL-8 release. Thus, HAT might promote PAR-2-mediated IL-8 production to accumulate inflammatory cells in the epidermal layer of psoriasis."xsd:string |
| http://purl.uniprot.org/citations/15102084 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.0022-202x.2004.22415.x"xsd:string |
| http://purl.uniprot.org/citations/15102084 | http://purl.uniprot.org/core/author | "Takemura T."xsd:string |
| http://purl.uniprot.org/citations/15102084 | http://purl.uniprot.org/core/author | "Fujiwara M."xsd:string |
| http://purl.uniprot.org/citations/15102084 | http://purl.uniprot.org/core/author | "Kawanami O."xsd:string |
| http://purl.uniprot.org/citations/15102084 | http://purl.uniprot.org/core/author | "Jin E."xsd:string |
| http://purl.uniprot.org/citations/15102084 | http://purl.uniprot.org/core/author | "Iwakiri K."xsd:string |
| http://purl.uniprot.org/citations/15102084 | http://purl.uniprot.org/core/author | "Yasuoka S."xsd:string |
| http://purl.uniprot.org/citations/15102084 | http://purl.uniprot.org/core/author | "Takezaki S."xsd:string |
| http://purl.uniprot.org/citations/15102084 | http://purl.uniprot.org/core/author | "Ghazizadeh M."xsd:string |
| http://purl.uniprot.org/citations/15102084 | http://purl.uniprot.org/core/author | "Kawana S."xsd:string |
| http://purl.uniprot.org/citations/15102084 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15102084 | http://purl.uniprot.org/core/name | "J Invest Dermatol"xsd:string |
| http://purl.uniprot.org/citations/15102084 | http://purl.uniprot.org/core/pages | "937-944"xsd:string |
| http://purl.uniprot.org/citations/15102084 | http://purl.uniprot.org/core/title | "Human airway trypsin-like protease induces PAR-2-mediated IL-8 release in psoriasis vulgaris."xsd:string |
| http://purl.uniprot.org/citations/15102084 | http://purl.uniprot.org/core/volume | "122"xsd:string |
| http://purl.uniprot.org/citations/15102084 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15102084 |
| http://purl.uniprot.org/citations/15102084 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15102084 |
| http://purl.uniprot.org/uniprot/#_A8K2M4-mappedCitation-15102084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15102084 |
| http://purl.uniprot.org/uniprot/#_A0A7U3S0Q4-mappedCitation-15102084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15102084 |
| http://purl.uniprot.org/uniprot/#_B4DL57-mappedCitation-15102084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15102084 |
| http://purl.uniprot.org/uniprot/#_P10145-mappedCitation-15102084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15102084 |
| http://purl.uniprot.org/uniprot/#_P55085-mappedCitation-15102084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15102084 |
| http://purl.uniprot.org/uniprot/#_O60235-mappedCitation-15102084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15102084 |