| http://purl.uniprot.org/citations/15102704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15102704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15102704 | http://www.w3.org/2000/01/rdf-schema#comment | "T-box genes form a large family of conserved transcription factors with diverse roles in animal development, but so far functions for only a few have been studied in detail. Here we show that four Caenorhabditis elegans T-box genes and the even-skipped-like homeobox gene vab-7 function within a regulatory network to control embryonic patterning and morphogenesis. tbx-8 and tbx-9 have functionally redundant roles in the intercalation of posterior dorsal hypodermal cells, in muscle cell positioning and in intestinal development. Inhibiting tbx-9 alone using RNA interference (RNAi) produces worms that have a thickened, 'bobbed tail' phenotype, similar to that seen in mutants of vab-7, which itself has been shown to pattern posterior muscle and hypodermal cells. In support of the view that these genes function in the same pathway, we find that tbx-8 and tbx-9 are both necessary and sufficient for vab-7 expression. In addition, a third T-box gene, tbx-30, acts to repress vab-7 expression in the anterior of embryos. We further show that vab-7 itself represses the T-box gene mab-9 in posterior cells. Thus, during posterior patterning in C. elegans, there are multiple interactions between T-box genes and the vab-7 homeobox gene. Evolutionary parallels in other organisms suggest that regulatory interactions between T-box genes and even-skipped homologues are conserved."xsd:string |
| http://purl.uniprot.org/citations/15102704 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.01110"xsd:string |
| http://purl.uniprot.org/citations/15102704 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.01110"xsd:string |
| http://purl.uniprot.org/citations/15102704 | http://purl.uniprot.org/core/author | "Woollard A."xsd:string |
| http://purl.uniprot.org/citations/15102704 | http://purl.uniprot.org/core/author | "Woollard A."xsd:string |
| http://purl.uniprot.org/citations/15102704 | http://purl.uniprot.org/core/author | "Maxwell S."xsd:string |
| http://purl.uniprot.org/citations/15102704 | http://purl.uniprot.org/core/author | "Maxwell S."xsd:string |
| http://purl.uniprot.org/citations/15102704 | http://purl.uniprot.org/core/author | "Ahringer J."xsd:string |
| http://purl.uniprot.org/citations/15102704 | http://purl.uniprot.org/core/author | "Ahringer J."xsd:string |
| http://purl.uniprot.org/citations/15102704 | http://purl.uniprot.org/core/author | "Pocock R."xsd:string |
| http://purl.uniprot.org/citations/15102704 | http://purl.uniprot.org/core/author | "Pocock R."xsd:string |
| http://purl.uniprot.org/citations/15102704 | http://purl.uniprot.org/core/author | "Mitsch M."xsd:string |
| http://purl.uniprot.org/citations/15102704 | http://purl.uniprot.org/core/author | "Mitsch M."xsd:string |
| http://purl.uniprot.org/citations/15102704 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15102704 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15102704 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/15102704 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/15102704 | http://purl.uniprot.org/core/pages | "2373-2385"xsd:string |
| http://purl.uniprot.org/citations/15102704 | http://purl.uniprot.org/core/pages | "2373-2385"xsd:string |
| http://purl.uniprot.org/citations/15102704 | http://purl.uniprot.org/core/title | "A regulatory network of T-box genes and the even-skipped homologue vab-7 controls patterning and morphogenesis in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/15102704 | http://purl.uniprot.org/core/title | "A regulatory network of T-box genes and the even-skipped homologue vab-7 controls patterning and morphogenesis in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/15102704 | http://purl.uniprot.org/core/volume | "131"xsd:string |
| http://purl.uniprot.org/citations/15102704 | http://purl.uniprot.org/core/volume | "131"xsd:string |