| http://purl.uniprot.org/citations/15103019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15103019 | http://www.w3.org/2000/01/rdf-schema#comment | "Differentiation is a highly regulated process whereby cells become specialized to perform specific functions and lose the ability to perform others. In contrast, the question of whether dedifferentiation is a genetically determined process, or merely an unregulated loss of the differentiated state, has not been resolved. We show here that dedifferentiation in the social amoeba Dictyostelium discoideum relies on a sequence of events that is independent of the original developmental state and involves the coordinated expression of a specific set of genes. A defect in one of these genes, the histidine kinase dhkA, alters the kinetics of dedifferentiation and uncouples the progression of dedifferentiation events. These observations establish dedifferentiation as a genetically determined process and suggest the existence of a developmental checkpoint that ensures a return path to the undifferentiated state."xsd:string |
| http://purl.uniprot.org/citations/15103019 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0306983101"xsd:string |
| http://purl.uniprot.org/citations/15103019 | http://purl.uniprot.org/core/author | "Katoh M."xsd:string |
| http://purl.uniprot.org/citations/15103019 | http://purl.uniprot.org/core/author | "Kuwayama H."xsd:string |
| http://purl.uniprot.org/citations/15103019 | http://purl.uniprot.org/core/author | "Tanaka Y."xsd:string |
| http://purl.uniprot.org/citations/15103019 | http://purl.uniprot.org/core/author | "Xu Q."xsd:string |
| http://purl.uniprot.org/citations/15103019 | http://purl.uniprot.org/core/author | "Morio T."xsd:string |
| http://purl.uniprot.org/citations/15103019 | http://purl.uniprot.org/core/author | "Shaulsky G."xsd:string |
| http://purl.uniprot.org/citations/15103019 | http://purl.uniprot.org/core/author | "Shaw C."xsd:string |
| http://purl.uniprot.org/citations/15103019 | http://purl.uniprot.org/core/author | "Urushihara H."xsd:string |
| http://purl.uniprot.org/citations/15103019 | http://purl.uniprot.org/core/author | "Van Driessche N."xsd:string |
| http://purl.uniprot.org/citations/15103019 | http://purl.uniprot.org/core/author | "Obara S."xsd:string |
| http://purl.uniprot.org/citations/15103019 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15103019 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/15103019 | http://purl.uniprot.org/core/pages | "7005-7010"xsd:string |
| http://purl.uniprot.org/citations/15103019 | http://purl.uniprot.org/core/title | "An orderly retreat: Dedifferentiation is a regulated process."xsd:string |
| http://purl.uniprot.org/citations/15103019 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/15103019 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15103019 |
| http://purl.uniprot.org/citations/15103019 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15103019 |
| http://purl.uniprot.org/uniprot/#_P16168-mappedCitation-15103019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15103019 |
| http://purl.uniprot.org/uniprot/#_Q54U87-mappedCitation-15103019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15103019 |
| http://purl.uniprot.org/uniprot/#_Q54YG2-mappedCitation-15103019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15103019 |
| http://purl.uniprot.org/uniprot/#_P14328-mappedCitation-15103019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15103019 |
| http://purl.uniprot.org/uniprot/#_P14329-mappedCitation-15103019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15103019 |