| http://purl.uniprot.org/citations/15105425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15105425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15105425 | http://www.w3.org/2000/01/rdf-schema#comment | "In the human kinome, vaccinia-related kinase-1 (VRK1) is a new Ser-Thr kinase associated with proliferating tissues. VRK1 colocalizes with ATF2 in the nucleus and can form a stable complex. We have studied the phosphorylation of the transcription factor ATF2, which regulates gene expression by forming dimers with proteins with basic region-leucine zipper domains and recognizing cAMP-response element or AP1 sequences implicated in cellular responses to stress. VRK1 phosphorylates ATF2 mainly on Thr-73, stabilizing the ATF2 protein and increasing its intracellular level. Mutagenesis studies showed that Thr-73 and Ser-62 are implicated in ATF2 transcriptional activation by VRK1 detected in a functional assay based on ATF2 dimerization. VRK1 can activate the collagenase gene promoter that is regulated by ATF2 in a dose-dependent manner. Loss of kinase activity (K179E mutant) or the T73A substitution in ATF2 prevents both its accumulation and activation of transcription. VRK1 and JNK, which phosphorylates ATF2 in Thr-69 and Thr-71, have an additive effect on ATF2-dependent transcription at suboptimal doses. Therefore, two groups of amino acids in the ATF2 amino-terminal region can integrate different cellular signals mediated by at least five different kinases. VRK1 is an element of a novel signaling pathway that regulates gene transcription."xsd:string |
| http://purl.uniprot.org/citations/15105425 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m401009200"xsd:string |
| http://purl.uniprot.org/citations/15105425 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m401009200"xsd:string |
| http://purl.uniprot.org/citations/15105425 | http://purl.uniprot.org/core/author | "Santos C.R."xsd:string |
| http://purl.uniprot.org/citations/15105425 | http://purl.uniprot.org/core/author | "Santos C.R."xsd:string |
| http://purl.uniprot.org/citations/15105425 | http://purl.uniprot.org/core/author | "Lazo P.A."xsd:string |
| http://purl.uniprot.org/citations/15105425 | http://purl.uniprot.org/core/author | "Lazo P.A."xsd:string |
| http://purl.uniprot.org/citations/15105425 | http://purl.uniprot.org/core/author | "Sevilla A."xsd:string |
| http://purl.uniprot.org/citations/15105425 | http://purl.uniprot.org/core/author | "Sevilla A."xsd:string |
| http://purl.uniprot.org/citations/15105425 | http://purl.uniprot.org/core/author | "Vega F.M."xsd:string |
| http://purl.uniprot.org/citations/15105425 | http://purl.uniprot.org/core/author | "Vega F.M."xsd:string |
| http://purl.uniprot.org/citations/15105425 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15105425 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15105425 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15105425 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15105425 | http://purl.uniprot.org/core/pages | "27458-27465"xsd:string |
| http://purl.uniprot.org/citations/15105425 | http://purl.uniprot.org/core/pages | "27458-27465"xsd:string |
| http://purl.uniprot.org/citations/15105425 | http://purl.uniprot.org/core/title | "Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK."xsd:string |
| http://purl.uniprot.org/citations/15105425 | http://purl.uniprot.org/core/title | "Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK."xsd:string |
| http://purl.uniprot.org/citations/15105425 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/15105425 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/15105425 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15105425 |
| http://purl.uniprot.org/citations/15105425 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15105425 |