| http://purl.uniprot.org/citations/15107494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15107494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15107494 | http://www.w3.org/2000/01/rdf-schema#comment | "cENS-1/cERNI genes have been shown to be expressed very early during chicken embryonic development and as well as in pluripotent chicken embryonic stem (CES) cells. We have previously identified a promoter region, which is specifically active in CES cells compared to differentiated cells. In order to understand the molecular mechanisms which regulate the cENS-1/cERNI promoter, we analyzed the cis-acting elements of this promoter in CES and differentiated cells. We identified a short sequence, named the B region, 5'-CAAG TCCAGG CAAG-3', that exhibits a strong enhancer activity in CES and differentiated cells. Mutation of the B region in the whole cENS-1 promoter strongly decreases the promoter activity in CES cells, suggesting that this region is essential for activating the promoter. The B region is similar to the previously described response element for the transcription factor CP2 and we show by supershift experiments that a protein complex containing CP2 is bound to this B response element. All these results identify a nuclear factor belonging to the CP2 transcription factor family that is crucial for the activation of the cENS-1/cERNI promoter. The pattern of expression of cCP2 in early chicken embryo before gastrulation is very similar to that of cENS-1/cERNI which strongly suggests that cCP2 also plays an essential role in gene expression early in embryonic development."xsd:string |
| http://purl.uniprot.org/citations/15107494 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkh545"xsd:string |
| http://purl.uniprot.org/citations/15107494 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkh545"xsd:string |
| http://purl.uniprot.org/citations/15107494 | http://purl.uniprot.org/core/author | "Gruffat H."xsd:string |
| http://purl.uniprot.org/citations/15107494 | http://purl.uniprot.org/core/author | "Gruffat H."xsd:string |
| http://purl.uniprot.org/citations/15107494 | http://purl.uniprot.org/core/author | "Acloque H."xsd:string |
| http://purl.uniprot.org/citations/15107494 | http://purl.uniprot.org/core/author | "Acloque H."xsd:string |
| http://purl.uniprot.org/citations/15107494 | http://purl.uniprot.org/core/author | "Pain B."xsd:string |
| http://purl.uniprot.org/citations/15107494 | http://purl.uniprot.org/core/author | "Pain B."xsd:string |
| http://purl.uniprot.org/citations/15107494 | http://purl.uniprot.org/core/author | "Birot A.-M."xsd:string |
| http://purl.uniprot.org/citations/15107494 | http://purl.uniprot.org/core/author | "Birot A.-M."xsd:string |
| http://purl.uniprot.org/citations/15107494 | http://purl.uniprot.org/core/author | "Samarut J."xsd:string |
| http://purl.uniprot.org/citations/15107494 | http://purl.uniprot.org/core/author | "Samarut J."xsd:string |
| http://purl.uniprot.org/citations/15107494 | http://purl.uniprot.org/core/author | "Mey A."xsd:string |
| http://purl.uniprot.org/citations/15107494 | http://purl.uniprot.org/core/author | "Mey A."xsd:string |
| http://purl.uniprot.org/citations/15107494 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15107494 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15107494 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/15107494 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/15107494 | http://purl.uniprot.org/core/pages | "2259-2271"xsd:string |
| http://purl.uniprot.org/citations/15107494 | http://purl.uniprot.org/core/pages | "2259-2271"xsd:string |
| http://purl.uniprot.org/citations/15107494 | http://purl.uniprot.org/core/title | "Transcription factor cCP2 controls gene expression in chicken embryonic stem cells."xsd:string |
| http://purl.uniprot.org/citations/15107494 | http://purl.uniprot.org/core/title | "Transcription factor cCP2 controls gene expression in chicken embryonic stem cells."xsd:string |