| http://purl.uniprot.org/citations/15107833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15107833 | http://www.w3.org/2000/01/rdf-schema#comment | "Elevated Src protein levels and activity are associated with the development and progression of a variety of cancers. The consequences of deregulated Src activity have been studied extensively in cell culture; however, the effects of this deregulation in vivo, as well as the mechanisms of Src-induced tumorigenesis, remain poorly understood. In this study, the effect of expressing wild-type and constitutively active Drosophila Src-family kinases (SFKs) in the developing eye was examined. Overexpression of either wild-type Drosophila SFK (Src64 and Src42) is sufficient to induce ectopic proliferation in G1/G0-arrested, uncommitted cells in eye imaginal discs. In addition, both kinases trigger apoptosis in vivo, in a dosage-dependent manner. Constitutively active mutants are hypermorphic as they trigger proliferation and death more potently than their wild-type counterparts. Moreover, SFK-induced proliferation and apoptosis are largely independent events, as blocking ectopic proliferation does not block cell death. Further, DCsk (the Drosophila homolog of the C-terminal Src kinase) phosphorylates and interacts genetically with the wild-type SFKs, but not with the constitutively active mutants in which a conserved C-terminal tyrosine was mutated to phenylalanine, providing the first in vivo evidence that Csk regulates SFKs during development through phosphorylation of their C-terminal tyrosine."xsd:string |
| http://purl.uniprot.org/citations/15107833 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1207635"xsd:string |
| http://purl.uniprot.org/citations/15107833 | http://purl.uniprot.org/core/author | "Xu T."xsd:string |
| http://purl.uniprot.org/citations/15107833 | http://purl.uniprot.org/core/author | "Pedraza L.G."xsd:string |
| http://purl.uniprot.org/citations/15107833 | http://purl.uniprot.org/core/author | "Li D.M."xsd:string |
| http://purl.uniprot.org/citations/15107833 | http://purl.uniprot.org/core/author | "Stewart R.A."xsd:string |
| http://purl.uniprot.org/citations/15107833 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15107833 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/15107833 | http://purl.uniprot.org/core/pages | "4754-4762"xsd:string |
| http://purl.uniprot.org/citations/15107833 | http://purl.uniprot.org/core/title | "Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis."xsd:string |
| http://purl.uniprot.org/citations/15107833 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/15107833 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15107833 |
| http://purl.uniprot.org/citations/15107833 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15107833 |
| http://purl.uniprot.org/uniprot/Q8INJ8#attribution-9E6A60BD7938F2133365164F0131EB48 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15107833 |
| http://purl.uniprot.org/uniprot/Q7KSQ2#attribution-9E6A60BD7938F2133365164F0131EB48 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15107833 |
| http://purl.uniprot.org/uniprot/Q9VGK8#attribution-9E6A60BD7938F2133365164F0131EB48 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15107833 |
| http://purl.uniprot.org/uniprot/#_A1Z6I9-mappedCitation-15107833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15107833 |
| http://purl.uniprot.org/uniprot/#_M9MSK3-mappedCitation-15107833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15107833 |
| http://purl.uniprot.org/uniprot/#_M9NFP7-mappedCitation-15107833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15107833 |
| http://purl.uniprot.org/uniprot/#_P00528-mappedCitation-15107833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15107833 |
| http://purl.uniprot.org/uniprot/#_M9PFL5-mappedCitation-15107833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15107833 |
| http://purl.uniprot.org/uniprot/#_Q24106-mappedCitation-15107833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15107833 |
| http://purl.uniprot.org/uniprot/#_P16914-mappedCitation-15107833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15107833 |
| http://purl.uniprot.org/uniprot/#_Q7KSQ2-mappedCitation-15107833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15107833 |