| http://purl.uniprot.org/citations/15107989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15107989 | http://www.w3.org/2000/01/rdf-schema#comment | "The 2-5A/RNase L pathway belongs to the antiviral system induced by interferon (IFN). RNase L is an inactive endoribonuclease which is activated by 2'-5' oligoadenylate (2-5A) synthesized by 2',5'-oligoadenylate synthetases. Once activated, RNase L cleaves mRNA, inhibiting the protein synthesis, as well as 28S and 18S ribosomal RNA (rRNA), leading to ribosomal inactivation. In this study, we investigate the role of the RNase L pathway as a cell defence mechanism during Varicella-zoster virus (VZV) replication, and the importance of a 68-kDa protein named RNase L inhibitor (RLI), which specifically inhibits RNase L. We demonstrate that the RNase L and RLI transcripts levels remain constant in VZV-infected cells for 24 h and 12 h, respectively, after which they decrease until the end of the viral cycle. VZV does not significantly modulate the protein level of RNase L during the course of infection. Using an rRNA cleavage assay to analyse the RNase L catalytic activity, we demonstrate that VZV replication leads to a minimal cleavage of rRNA. Moreover, the overexpression of RLI in a permissive cell line has no significant effect on the VZV replication. We conclude that RNase L does not constitute a major cell defence mechanism against the VZV infection."xsd:string |
| http://purl.uniprot.org/citations/15107989 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00430-004-0220-7"xsd:string |
| http://purl.uniprot.org/citations/15107989 | http://purl.uniprot.org/core/author | "Desloges N."xsd:string |
| http://purl.uniprot.org/citations/15107989 | http://purl.uniprot.org/core/author | "Rahaus M."xsd:string |
| http://purl.uniprot.org/citations/15107989 | http://purl.uniprot.org/core/author | "Wolff M.H."xsd:string |
| http://purl.uniprot.org/citations/15107989 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15107989 | http://purl.uniprot.org/core/name | "Med Microbiol Immunol"xsd:string |
| http://purl.uniprot.org/citations/15107989 | http://purl.uniprot.org/core/pages | "25-31"xsd:string |
| http://purl.uniprot.org/citations/15107989 | http://purl.uniprot.org/core/title | "Varicella-zoster virus does not significantly induce cell defence mechanism mediated by the 2-5A/RNase L pathway during its replication cycle."xsd:string |
| http://purl.uniprot.org/citations/15107989 | http://purl.uniprot.org/core/volume | "194"xsd:string |
| http://purl.uniprot.org/citations/15107989 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15107989 |
| http://purl.uniprot.org/citations/15107989 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15107989 |
| http://purl.uniprot.org/uniprot/#_Q1A3D9-mappedCitation-15107989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15107989 |
| http://purl.uniprot.org/uniprot/#_Q05823-mappedCitation-15107989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15107989 |
| http://purl.uniprot.org/uniprot/#_P61221-mappedCitation-15107989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15107989 |
| http://purl.uniprot.org/uniprot/#_Q1RLL8-mappedCitation-15107989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15107989 |
| http://purl.uniprot.org/uniprot/Q1A3D9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15107989 |
| http://purl.uniprot.org/uniprot/Q05823 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15107989 |
| http://purl.uniprot.org/uniprot/Q1RLL8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15107989 |
| http://purl.uniprot.org/uniprot/P61221 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15107989 |