| http://purl.uniprot.org/citations/15111510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15111510 | http://www.w3.org/2000/01/rdf-schema#comment | "Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) is a transcriptional coactivator implicated in transcriptional programs of hepatic gluconeogenesis, oxidative phosphorylation, and insulin release by beta-cells. To study associations of the PGC-1alpha gene locus with carbohydrate metabolism and type 2 diabetes in humans, we identified several polymorphisms in the promoter region that were located in a haplotype block distinct from a second haplotype block containing part of intron 2 and extending beyond exon 13. Each block contained five common haplotypes. Oral glucose tolerance testing revealed associations of promoter haplotype combinations with 30- and 60-min postload plasma glucose levels, whereas haplotypes in both blocks were associated with indexes of beta-cell function. The associations of promoter haplotypes are supported by functional studies showing that some polymorphisms are located in transcription factor binding sites and affect transactivation in an allele-specific manner. By comparing patients with type 2 diabetes and control subjects, we observed borderline significant differences of four-loci haplotype distributions in the downstream haplotype block. Moreover, the haplotype that was associated with the strongest insulin response to glucose conferred the lowest risk of type 2 diabetes (P < 0.01). Thus, the PGC-1alpha gene locus influences carbohydrate metabolism and contributes to type 2 diabetes in the population studied."xsd:string |
| http://purl.uniprot.org/citations/15111510 | http://purl.org/dc/terms/identifier | "doi:10.2337/diabetes.53.5.1385"xsd:string |
| http://purl.uniprot.org/citations/15111510 | http://purl.uniprot.org/core/author | "Xie M."xsd:string |
| http://purl.uniprot.org/citations/15111510 | http://purl.uniprot.org/core/author | "Klein K."xsd:string |
| http://purl.uniprot.org/citations/15111510 | http://purl.uniprot.org/core/author | "Patsch W."xsd:string |
| http://purl.uniprot.org/citations/15111510 | http://purl.uniprot.org/core/author | "Oberkofler H."xsd:string |
| http://purl.uniprot.org/citations/15111510 | http://purl.uniprot.org/core/author | "Paulweber B."xsd:string |
| http://purl.uniprot.org/citations/15111510 | http://purl.uniprot.org/core/author | "Krempler F."xsd:string |
| http://purl.uniprot.org/citations/15111510 | http://purl.uniprot.org/core/author | "Iglseder B."xsd:string |
| http://purl.uniprot.org/citations/15111510 | http://purl.uniprot.org/core/author | "Linnemayr V."xsd:string |
| http://purl.uniprot.org/citations/15111510 | http://purl.uniprot.org/core/author | "Weitgasser R."xsd:string |
| http://purl.uniprot.org/citations/15111510 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15111510 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/15111510 | http://purl.uniprot.org/core/pages | "1385-1393"xsd:string |
| http://purl.uniprot.org/citations/15111510 | http://purl.uniprot.org/core/title | "Complex haplotypes of the PGC-1alpha gene are associated with carbohydrate metabolism and type 2 diabetes."xsd:string |
| http://purl.uniprot.org/citations/15111510 | http://purl.uniprot.org/core/volume | "53"xsd:string |
| http://purl.uniprot.org/citations/15111510 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15111510 |
| http://purl.uniprot.org/citations/15111510 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15111510 |
| http://purl.uniprot.org/uniprot/#_Q07869-mappedCitation-15111510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15111510 |
| http://purl.uniprot.org/uniprot/#_B7Z7E0-mappedCitation-15111510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15111510 |
| http://purl.uniprot.org/uniprot/#_B0QYX1-mappedCitation-15111510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15111510 |
| http://purl.uniprot.org/uniprot/#_B0QYX2-mappedCitation-15111510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15111510 |
| http://purl.uniprot.org/uniprot/#_B2R4U0-mappedCitation-15111510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15111510 |
| http://purl.uniprot.org/uniprot/#_F1D8S4-mappedCitation-15111510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15111510 |