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http://purl.uniprot.org/citations/15113995http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15113995http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

Carriage of HLA-B60 has been shown to increase the risk of ankylosing spondylitis (AS) in B27-positive Caucasian patients, but the association in B27-negative cases is less certain. This study assessed HLA class I gene associations in Chinese HLA-B27-negative AS patients.

Methods

Forty-one Chinese HLA-B27-negative AS patients fulfilling the modified New York diagnostic criteria for AS were recruited, and 11 383 HLA-B27-negative blood donors were used for comparison. HLA-A and -B typing was done with the microlymphocytotoxicity assay.

Results

Among the B27-negative AS patients, 21 were male and 20 were female. Of HLA-B alleles, only B60 and B61 significantly increased susceptibility to AS in HLA-B27-negative patients (P<0.001).

Conclusions

In Taiwan Chinese, carriage of B60 is increased in HLA-B27-negative AS patients. The association between B61 and HLA-B27-negative AS patients has not been reported previously. Whether the gene involved is HLA-B60 or B61 or another gene in linkage disequilibrium with these genes is unknown."xsd:string
http://purl.uniprot.org/citations/15113995http://purl.org/dc/terms/identifier"doi:10.1093/rheumatology/keh193"xsd:string
http://purl.uniprot.org/citations/15113995http://purl.uniprot.org/core/author"Tsai W.C."xsd:string
http://purl.uniprot.org/citations/15113995http://purl.uniprot.org/core/author"Tsai C.Y."xsd:string
http://purl.uniprot.org/citations/15113995http://purl.uniprot.org/core/author"Chou C.T."xsd:string
http://purl.uniprot.org/citations/15113995http://purl.uniprot.org/core/author"Wei J.C."xsd:string
http://purl.uniprot.org/citations/15113995http://purl.uniprot.org/core/author"Lin H.S."xsd:string
http://purl.uniprot.org/citations/15113995http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15113995http://purl.uniprot.org/core/name"Rheumatology (Oxford)"xsd:string
http://purl.uniprot.org/citations/15113995http://purl.uniprot.org/core/pages"839-842"xsd:string
http://purl.uniprot.org/citations/15113995http://purl.uniprot.org/core/title"HLA-B60 and B61 are strongly associated with ankylosing spondylitis in HLA-B27-negative Taiwan Chinese patients."xsd:string
http://purl.uniprot.org/citations/15113995http://purl.uniprot.org/core/volume"43"xsd:string
http://purl.uniprot.org/citations/15113995http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15113995
http://purl.uniprot.org/citations/15113995http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15113995
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