| http://purl.uniprot.org/citations/15115762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15115762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15115762 | http://www.w3.org/2000/01/rdf-schema#comment | "Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disorder caused by a CAG repeat expansion in the SCA7 gene leading to elongation of a polyglutamine tract in ataxin-7, a protein of unknown function. A putative ataxin-7 yeast orthologue (SGF73) has been identified recently as a new component of the SAGA (Spt/Ada/Gcn5 acetylase) multisubunit complex, a coactivator required for transcription of a subset of RNA polymerase II-dependent genes. We show here that ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). In agreement, immunoprecipitation of ataxin-7 retained a histone acetyltransferase activity, characteristic for TFTC-like complexes. We further identified a minimal domain in ataxin-7 that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution, allowing the identification of a SCA7 gene family. We showed that this domain contains a conserved Cys(3)His motif that binds zinc, forming a new zinc-binding domain. Finally, polyglutamine expansion in ataxin-7 did not affect its incorporation into TFTC/STAGA complexes purified from SCA7 patient cells. We demonstrate here that ataxin-7 is the human orthologue of the yeast SAGA SGF73 subunit and is a bona fide subunit of the human TFTC-like transcriptional complexes."xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddh139"xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddh139"xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.uniprot.org/core/author | "Klein F."xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.uniprot.org/core/author | "Klein F."xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.uniprot.org/core/author | "Van-Dorsselaer A."xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.uniprot.org/core/author | "Van-Dorsselaer A."xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.uniprot.org/core/author | "Weber C."xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.uniprot.org/core/author | "Weber C."xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.uniprot.org/core/author | "Mandel J.L."xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.uniprot.org/core/author | "Mandel J.L."xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.uniprot.org/core/author | "Robert F."xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.uniprot.org/core/author | "Robert F."xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.uniprot.org/core/author | "Potier N."xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.uniprot.org/core/author | "Potier N."xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.uniprot.org/core/author | "Tora L."xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.uniprot.org/core/author | "Tora L."xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.uniprot.org/core/author | "Devys D."xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.uniprot.org/core/author | "Devys D."xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.uniprot.org/core/author | "Hardy S."xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.uniprot.org/core/author | "Hardy S."xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.uniprot.org/core/author | "Sasorith S."xsd:string |
| http://purl.uniprot.org/citations/15115762 | http://purl.uniprot.org/core/author | "Sasorith S."xsd:string |