| http://purl.uniprot.org/citations/15116070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15116070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15116070 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitogen-activated protein kinases (MAPKs) are integral to the mechanisms by which cells respond to physiological stimuli and to a wide variety of environmental stresses. MAPK cascades can be inactivated at the MAPK activation step by members of the MAPK phosphatase (MKP) family. However, the components that act in MKP-regulated pathways have not been well characterized in the context of whole organisms. Here we characterize the Caenorhabditis elegans vhp-1 gene, encoding an MKP that acts preferentially on the c-Jun N-terminal kinase (JNK) and p38 MAPKs. We found that animals defective in vhp-1 are arrested during larval development. This vhp-1 defect is suppressed by loss-of-function mutations in the kgb-1, mek-1, and mlk-1 genes encoding a JNK-like MAPK, an MKK7-type MAPKK, and an MLK-type MAPKKK, respectively. The genetic and biochemical data presented here demonstrate a critical role for VHP-1 in the KGB-1 pathway. Loss-of-function mutations in each component in the KGB-1 pathway result in hypersensitivity to heavy metals. These results suggest that VHP-1 plays a pivotal role in the integration and fine-tuning of the stress response regulated by the KGB-1 MAPK pathway."xsd:string |
| http://purl.uniprot.org/citations/15116070 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600226"xsd:string |
| http://purl.uniprot.org/citations/15116070 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600226"xsd:string |
| http://purl.uniprot.org/citations/15116070 | http://purl.uniprot.org/core/author | "Ausubel F.M."xsd:string |
| http://purl.uniprot.org/citations/15116070 | http://purl.uniprot.org/core/author | "Ausubel F.M."xsd:string |
| http://purl.uniprot.org/citations/15116070 | http://purl.uniprot.org/core/author | "Kim D.H."xsd:string |
| http://purl.uniprot.org/citations/15116070 | http://purl.uniprot.org/core/author | "Kim D.H."xsd:string |
| http://purl.uniprot.org/citations/15116070 | http://purl.uniprot.org/core/author | "Mizuno T."xsd:string |
| http://purl.uniprot.org/citations/15116070 | http://purl.uniprot.org/core/author | "Mizuno T."xsd:string |
| http://purl.uniprot.org/citations/15116070 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/15116070 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/15116070 | http://purl.uniprot.org/core/author | "Terada T."xsd:string |
| http://purl.uniprot.org/citations/15116070 | http://purl.uniprot.org/core/author | "Terada T."xsd:string |
| http://purl.uniprot.org/citations/15116070 | http://purl.uniprot.org/core/author | "Kondo T."xsd:string |
| http://purl.uniprot.org/citations/15116070 | http://purl.uniprot.org/core/author | "Kondo T."xsd:string |
| http://purl.uniprot.org/citations/15116070 | http://purl.uniprot.org/core/author | "Adachi M."xsd:string |
| http://purl.uniprot.org/citations/15116070 | http://purl.uniprot.org/core/author | "Adachi M."xsd:string |
| http://purl.uniprot.org/citations/15116070 | http://purl.uniprot.org/core/author | "Nishida E."xsd:string |
| http://purl.uniprot.org/citations/15116070 | http://purl.uniprot.org/core/author | "Nishida E."xsd:string |
| http://purl.uniprot.org/citations/15116070 | http://purl.uniprot.org/core/author | "Hisamoto N."xsd:string |
| http://purl.uniprot.org/citations/15116070 | http://purl.uniprot.org/core/author | "Hisamoto N."xsd:string |
| http://purl.uniprot.org/citations/15116070 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15116070 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |