| http://purl.uniprot.org/citations/15118108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15118108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15118108 | http://www.w3.org/2000/01/rdf-schema#comment | "PIKE-A (PIKE-activating Akt), an isoform of PIKE GTPase that enhances phosphatidylinositol 3-kinase (PI3-kinase) activity, specifically binds to active Akt but not PI3-kinase. PIKE-A stimulates Akt activity in a GTP-dependent manner and promotes invasiveness of cancer cell lines. Here, we show that PIKE-A is amplified in a variety of human cancers and that amplified PIKE-A directly stimulates Akt and inhibits apoptosis compared to cells with normal PIKE-A copy number. Overexpression of PIKE-A wild-type but not dominant-negative mutant stimulates Akt activity and prevents apoptosis. Moreover, knockdown of PIKE-A diminishes Akt activity and increases apoptosis. Our findings suggest that PIKE-A amplification contributes to cancer cell survival and progression by inhibiting apoptosis through up-regulating Akt."xsd:string |
| http://purl.uniprot.org/citations/15118108 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0400921101"xsd:string |
| http://purl.uniprot.org/citations/15118108 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0400921101"xsd:string |
| http://purl.uniprot.org/citations/15118108 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/15118108 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/15118108 | http://purl.uniprot.org/core/author | "Ye K."xsd:string |
| http://purl.uniprot.org/citations/15118108 | http://purl.uniprot.org/core/author | "Ye K."xsd:string |
| http://purl.uniprot.org/citations/15118108 | http://purl.uniprot.org/core/author | "Allard P."xsd:string |
| http://purl.uniprot.org/citations/15118108 | http://purl.uniprot.org/core/author | "Allard P."xsd:string |
| http://purl.uniprot.org/citations/15118108 | http://purl.uniprot.org/core/author | "Ahn J.-Y."xsd:string |
| http://purl.uniprot.org/citations/15118108 | http://purl.uniprot.org/core/author | "Ahn J.-Y."xsd:string |
| http://purl.uniprot.org/citations/15118108 | http://purl.uniprot.org/core/author | "Kroll T.G."xsd:string |
| http://purl.uniprot.org/citations/15118108 | http://purl.uniprot.org/core/author | "Kroll T.G."xsd:string |
| http://purl.uniprot.org/citations/15118108 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15118108 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15118108 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/15118108 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/15118108 | http://purl.uniprot.org/core/pages | "6993-6998"xsd:string |
| http://purl.uniprot.org/citations/15118108 | http://purl.uniprot.org/core/pages | "6993-6998"xsd:string |
| http://purl.uniprot.org/citations/15118108 | http://purl.uniprot.org/core/title | "PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt."xsd:string |
| http://purl.uniprot.org/citations/15118108 | http://purl.uniprot.org/core/title | "PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt."xsd:string |
| http://purl.uniprot.org/citations/15118108 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/15118108 | http://purl.uniprot.org/core/volume | "101"xsd:string |