| http://purl.uniprot.org/citations/15123258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15123258 | http://www.w3.org/2000/01/rdf-schema#comment | "Treating yeast cells with rapamycin, a small molecule that inhibits the TOR proteins, leads to the repression of many genes. Consistent with prior studies, we find that RPD3, which encodes a histone deacetylase (HDAC), is required for repression upon rapamycin treatment. To elucidate the mechanism underlying RPD3-mediated repression, we screened all promoters in yeast for occupancy by Rpd3p before and after treatment with rapamycin. We find that Rpd3p binds to the promoters of rapamycin-repressible genes only following treatment. These data conflict with a previously proposed model suggesting that Rpd3p is constitutively bound to rapamycin-repressible genes and becomes active only after a stimulus such as treatment with rapamycin. Rather, the comprehensive analysis presented here strongly supports a model in which recruitment of Rpd3p to gene promoters is a regulated step in the control of gene repression."xsd:string |
| http://purl.uniprot.org/citations/15123258 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chembiol.2004.03.001"xsd:string |
| http://purl.uniprot.org/citations/15123258 | http://purl.uniprot.org/core/author | "Bernstein B.E."xsd:string |
| http://purl.uniprot.org/citations/15123258 | http://purl.uniprot.org/core/author | "Schreiber S.L."xsd:string |
| http://purl.uniprot.org/citations/15123258 | http://purl.uniprot.org/core/author | "Shamji A.F."xsd:string |
| http://purl.uniprot.org/citations/15123258 | http://purl.uniprot.org/core/author | "Humphrey E.L."xsd:string |
| http://purl.uniprot.org/citations/15123258 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15123258 | http://purl.uniprot.org/core/name | "Chem Biol"xsd:string |
| http://purl.uniprot.org/citations/15123258 | http://purl.uniprot.org/core/pages | "295-299"xsd:string |
| http://purl.uniprot.org/citations/15123258 | http://purl.uniprot.org/core/title | "Rpd3p relocation mediates a transcriptional response to rapamycin in yeast."xsd:string |
| http://purl.uniprot.org/citations/15123258 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/15123258 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15123258 |
| http://purl.uniprot.org/citations/15123258 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15123258 |
| http://purl.uniprot.org/uniprot/#_P35718-mappedCitation-15123258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15123258 |
| http://purl.uniprot.org/uniprot/#_P0CX48-mappedCitation-15123258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15123258 |
| http://purl.uniprot.org/uniprot/#_P46669-mappedCitation-15123258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15123258 |
| http://purl.uniprot.org/uniprot/#_P17076-mappedCitation-15123258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15123258 |
| http://purl.uniprot.org/uniprot/#_P05738-mappedCitation-15123258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15123258 |
| http://purl.uniprot.org/uniprot/#_P22579-mappedCitation-15123258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15123258 |
| http://purl.uniprot.org/uniprot/#_P32561-mappedCitation-15123258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15123258 |
| http://purl.uniprot.org/uniprot/#_P38712-mappedCitation-15123258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15123258 |
| http://purl.uniprot.org/uniprot/P22579 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15123258 |
| http://purl.uniprot.org/uniprot/P17076 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15123258 |
| http://purl.uniprot.org/uniprot/P0CX48 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15123258 |