| http://purl.uniprot.org/citations/15123625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15123625 | http://www.w3.org/2000/01/rdf-schema#comment | "Covalent modification of many transcription factors with SUMO-1 is emerging as a key role of trans-activational regulation. Here, we demonstrate that peroxisome proliferator-activated receptor (PPAR) gamma, which is a ligand-activated nuclear receptor, is modified by SUMO-1. Sumoylation of PPARgamma mainly occurs at a lysine residue within the activation function 1 domain. Furthermore, we show that the PIAS family proteins, PIAS1 and PIASxbeta, function as E3 ligases (ubiquitin-protein isopeptide ligase) for PPARgamma. PPARgamma interacts directly with PIASxbeta in a ligand-independent manner. Analysis using a PPARgamma mutant with a disrupted sumoylation site shows that modification of PPARgamma by SUMO-1 represses its transcriptional activity. Interestingly, PIASxbeta and Ubc9 enhance the transcriptional activity of PPARgamma independent of PPARgamma sumoylation. Furthermore, PPARgamma ligand-induced apoptosis in a human hepatoblastoma cell line, HepG2, is significantly enhanced by ectopic production of the sumoylation-mutant PPARgamma. These results suggest that the PPARgamma-dependent transactivation pathway seems to be modulated by SUMO-1 modification and may serve as a novel target for apoptosis-induction therapy in cancer cells."xsd:string |
| http://purl.uniprot.org/citations/15123625 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m403866200"xsd:string |
| http://purl.uniprot.org/citations/15123625 | http://purl.uniprot.org/core/author | "Ohshima T."xsd:string |
| http://purl.uniprot.org/citations/15123625 | http://purl.uniprot.org/core/author | "Koga H."xsd:string |
| http://purl.uniprot.org/citations/15123625 | http://purl.uniprot.org/core/author | "Shimotohno K."xsd:string |
| http://purl.uniprot.org/citations/15123625 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15123625 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15123625 | http://purl.uniprot.org/core/pages | "29551-29557"xsd:string |
| http://purl.uniprot.org/citations/15123625 | http://purl.uniprot.org/core/title | "Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification."xsd:string |
| http://purl.uniprot.org/citations/15123625 | http://purl.uniprot.org/core/volume | "279"xsd:string |
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