| http://purl.uniprot.org/citations/15125834 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15125834 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15125834 | http://www.w3.org/2000/01/rdf-schema#comment | "Norepinephrine released by the sympathetic nerve terminals regulates the immune system primarily via its stimulation of beta(2)-adrenergic receptor (beta(2)AR), but the underlying molecular mechanisms remain to be elicited. Beta(2)AR, a well-studied G protein-coupled receptor (GPCR), is functionally regulated by beta-arrestin2, which not only causes receptor desensitization and internalization but also serves as a signaling molecule in GPCR signal transduction. Here we show that beta-arrestin2 directly interacts with IkappaBalpha (inhibitor of NF-kappaB, the key molecule in innate and adaptive immunity) and thus prevents the phosphorylation and degradation of IkappaBalpha. Consequently, beta-arrestin2 effectively modulates activation of NF-kappaB and expression of NF-kappaB target genes. Moreover, stimulation of beta(2)AR significantly enhances beta-arrestin2-IkappaBalpha interaction and greatly promotes beta-arrestin2 stabilization of IkappaBalpha, indicating that beta-arrestin2 mediates a crosstalk between beta(2)AR and NF-kappaB signaling pathways. Taken together, the current study may present a novel mechanism for regulation of the immune system by the sympathetic nervous system."xsd:string |
| http://purl.uniprot.org/citations/15125834 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(04)00216-3"xsd:string |
| http://purl.uniprot.org/citations/15125834 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(04)00216-3"xsd:string |
| http://purl.uniprot.org/citations/15125834 | http://purl.uniprot.org/core/author | "Gao H."xsd:string |
| http://purl.uniprot.org/citations/15125834 | http://purl.uniprot.org/core/author | "Gao H."xsd:string |
| http://purl.uniprot.org/citations/15125834 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/15125834 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/15125834 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/15125834 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/15125834 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/15125834 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/15125834 | http://purl.uniprot.org/core/author | "Luan B."xsd:string |
| http://purl.uniprot.org/citations/15125834 | http://purl.uniprot.org/core/author | "Luan B."xsd:string |
| http://purl.uniprot.org/citations/15125834 | http://purl.uniprot.org/core/author | "Pei G."xsd:string |
| http://purl.uniprot.org/citations/15125834 | http://purl.uniprot.org/core/author | "Pei G."xsd:string |
| http://purl.uniprot.org/citations/15125834 | http://purl.uniprot.org/core/author | "Qu B."xsd:string |
| http://purl.uniprot.org/citations/15125834 | http://purl.uniprot.org/core/author | "Qu B."xsd:string |
| http://purl.uniprot.org/citations/15125834 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15125834 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15125834 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/15125834 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/15125834 | http://purl.uniprot.org/core/pages | "303-317"xsd:string |
| http://purl.uniprot.org/citations/15125834 | http://purl.uniprot.org/core/pages | "303-317"xsd:string |