| http://purl.uniprot.org/citations/15128794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15128794 | http://www.w3.org/2000/01/rdf-schema#comment | "NK T cells are a unique lymphocyte population that have developmental requirements distinct from conventional T cells. Mice lacking the tyrosine kinase Fyn have 5-to 10-fold fewer mature NK T cells. This study shows that Fyn-deficient mice have decreased numbers of NK1.1(-) NK T cell progenitors as well. 5-Bromo-2'-deoxyuridine-labeling studies indicate that the NK T cells remaining in fyn(-/-) mice exhibit a similar turnover rate as wild-type cells. The fyn(-/-) NK T cells respond to alpha-galactosylceramide, a ligand recognized by NK T cells, and produce cytokines, but have depressed proliferative capacity. Transgenic expression of the NK T cell-specific TCR alpha-chain Valpha14Jalpha18 leads to a complete restoration of NK T cell numbers in fyn(-/-) mice. Together, these results suggest that Fyn may have a role before alpha-chain rearrangement rather than for positive selection or the peripheral upkeep of cell number. NK T cells can activate other lymphoid lineages via cytokine secretion. These secondary responses are impaired in Fyn-deficient mice, but occur normally in fyn mutants expressing the Valpha14Jalpha18 transgene. Because this transgene restores NK T cell numbers, the lack of secondary lymphocyte activation in the fyn-mutant mice is due to the decreased numbers of NK T cells present in the mutant, rather than an intrinsic defect in the ability of the other fyn(-/-) lymphoid populations to respond."xsd:string |
| http://purl.uniprot.org/citations/15128794 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.172.10.6093"xsd:string |
| http://purl.uniprot.org/citations/15128794 | http://purl.uniprot.org/core/author | "Jain S."xsd:string |
| http://purl.uniprot.org/citations/15128794 | http://purl.uniprot.org/core/author | "Yin L."xsd:string |
| http://purl.uniprot.org/citations/15128794 | http://purl.uniprot.org/core/author | "Stein P.L."xsd:string |
| http://purl.uniprot.org/citations/15128794 | http://purl.uniprot.org/core/author | "Gadue P."xsd:string |
| http://purl.uniprot.org/citations/15128794 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15128794 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15128794 | http://purl.uniprot.org/core/pages | "6093-6100"xsd:string |
| http://purl.uniprot.org/citations/15128794 | http://purl.uniprot.org/core/title | "Restoration of NK T cell development in fyn-mutant mice by a TCR reveals a requirement for Fyn during early NK T cell ontogeny."xsd:string |
| http://purl.uniprot.org/citations/15128794 | http://purl.uniprot.org/core/volume | "172"xsd:string |
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