| http://purl.uniprot.org/citations/15128910 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15128910 | http://www.w3.org/2000/01/rdf-schema#comment | "Matrix metalloproteinases (MMP) are likely effectors of normal lung development, especially branching morphogenesis, angiogenesis, and extracellular matrix degradation. Because hyperoxia exposure (>95% O(2)) from d 4 to 14 in newborn rat pups leads to arrest of alveolarization and mimics newborn chronic lung disease, we tested whether hyperoxia altered MMP-2 and -9 mRNA, protein, and enzymatic activity, and the mRNA and protein expression of the endogenous tissue inhibitor of MMP, TIMP-1. No changes due to hyperoxia exposure were observed in MMP-2 mRNA or pro-enzyme (72 kD) protein levels between d 6 and 14, although the overall protein mass and zymographic activity of the active (68 kD) enzyme were diminished (p < 0.05, ANOVA). However, hyperoxia significantly decreased levels of MMP-9 mRNA and pro-MMP-9 protein and diminished overall MMP-9 pro-enzyme activity. TIMP-1 mRNA was not elevated by hyperoxia until d 14, but protein levels were significantly (p < 0.001) elevated by hyperoxia from d 9 to 14. To estimate the potential of MMP inhibition to arrest alveolarization, administration of doxycycline (20 mg/kg, twice daily by gavage), a pan-MMP proteolysis inhibitor, arrested lung alveolarization. We conclude that hyperoxia decreases MMP-9 mRNA, protein, and activity and elevates TIMP-1 protein, and these changes have the potential to contribute to the arrest of normal lung development."xsd:string |
| http://purl.uniprot.org/citations/15128910 | http://purl.org/dc/terms/identifier | "doi:10.1203/01.pdr.0000130658.45564.1f"xsd:string |
| http://purl.uniprot.org/citations/15128910 | http://purl.uniprot.org/core/author | "Fang X."xsd:string |
| http://purl.uniprot.org/citations/15128910 | http://purl.uniprot.org/core/author | "Hosford G.E."xsd:string |
| http://purl.uniprot.org/citations/15128910 | http://purl.uniprot.org/core/author | "Olson D.M."xsd:string |
| http://purl.uniprot.org/citations/15128910 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15128910 | http://purl.uniprot.org/core/name | "Pediatr Res"xsd:string |
| http://purl.uniprot.org/citations/15128910 | http://purl.uniprot.org/core/pages | "26-34"xsd:string |
| http://purl.uniprot.org/citations/15128910 | http://purl.uniprot.org/core/title | "Hyperoxia decreases matrix metalloproteinase-9 and increases tissue inhibitor of matrix metalloproteinase-1 protein in the newborn rat lung: association with arrested alveolarization."xsd:string |
| http://purl.uniprot.org/citations/15128910 | http://purl.uniprot.org/core/volume | "56"xsd:string |
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