| http://purl.uniprot.org/citations/15130468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15130468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15130468 | http://www.w3.org/2000/01/rdf-schema#comment | "Uridine-cytidine kinase (UCK) catalyzes the phosphorylation of uridine and cytidine and activates pharmacological ribonucleoside analogs. Here we present the crystal structures of human UCK alone and in complexes with a substrate, cytidine, a feedback inhibitor, CTP or UTP, and with phosphorylation products, CMP and ADP, respectively. Free UCK takes an alpha/beta mononucleotide binding fold and exists as a homotetramer with 222 symmetry. Upon inhibitor binding, one loop region was loosened, causing the UCK tetramer to be distorted. Upon cytidine binding, a large induced fit was observed at the uridine/cytidine binding site, which endows UCK with a strict specificity for pyrimidine ribonucleosides. The first UCK structure provided the structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase, which give clues for the design of novel antitumor and antiviral ribonucleoside analogs that inhibit RNA synthesis."xsd:string |
| http://purl.uniprot.org/citations/15130468 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2004.02.038"xsd:string |
| http://purl.uniprot.org/citations/15130468 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2004.02.038"xsd:string |
| http://purl.uniprot.org/citations/15130468 | http://purl.uniprot.org/core/author | "Inagaki F."xsd:string |
| http://purl.uniprot.org/citations/15130468 | http://purl.uniprot.org/core/author | "Inagaki F."xsd:string |
| http://purl.uniprot.org/citations/15130468 | http://purl.uniprot.org/core/author | "Matsuda A."xsd:string |
| http://purl.uniprot.org/citations/15130468 | http://purl.uniprot.org/core/author | "Matsuda A."xsd:string |
| http://purl.uniprot.org/citations/15130468 | http://purl.uniprot.org/core/author | "Fukushima M."xsd:string |
| http://purl.uniprot.org/citations/15130468 | http://purl.uniprot.org/core/author | "Fukushima M."xsd:string |
| http://purl.uniprot.org/citations/15130468 | http://purl.uniprot.org/core/author | "Koizumi K."xsd:string |
| http://purl.uniprot.org/citations/15130468 | http://purl.uniprot.org/core/author | "Koizumi K."xsd:string |
| http://purl.uniprot.org/citations/15130468 | http://purl.uniprot.org/core/author | "Suzuki N.N."xsd:string |
| http://purl.uniprot.org/citations/15130468 | http://purl.uniprot.org/core/author | "Suzuki N.N."xsd:string |
| http://purl.uniprot.org/citations/15130468 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15130468 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15130468 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/15130468 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/15130468 | http://purl.uniprot.org/core/pages | "751-764"xsd:string |
| http://purl.uniprot.org/citations/15130468 | http://purl.uniprot.org/core/pages | "751-764"xsd:string |
| http://purl.uniprot.org/citations/15130468 | http://purl.uniprot.org/core/title | "Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase."xsd:string |
| http://purl.uniprot.org/citations/15130468 | http://purl.uniprot.org/core/title | "Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase."xsd:string |
| http://purl.uniprot.org/citations/15130468 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/15130468 | http://purl.uniprot.org/core/volume | "12"xsd:string |