| http://purl.uniprot.org/citations/15131548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15131548 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundA point mutation in the gene encoding coagulation factor V is a cause of resistance against activated protein C. The presence of factor V Leiden is linked to 50% of congenital defects causing venous thrombosis. Its relationship to arterial thrombosis, particularly to myocardial infarction, has not been defined. Therefore, we performed a study on the role of factor V Leiden in patients with myocardial infarction. The study was carried out in Bavarians of German origin, a relatively homogeneous population.Methods and resultsThe study group consisted of 507 patients with documented myocardial infarction (77.5% (393/507) men, 22.5% (114/507) women), with a mean age of 56.1 (range 18-86) years. Strict criteria for patient selection and highly sensitive and specific functional tests for factor V Leiden were used. In addition, all patients with pathological test results were genotyped. The prevalence of factor V Leiden in patients with myocardial infarction was 8.7% (44/507), a significant increase in the prevalence of this mutation compared with the control group (3.7%, P =.0025). The odds ratio was 2.46 (95% CI 1.35-4.50).ConclusionsA significantly increased prevalence of factor V Leiden in patients with documented myocardial infarction was seen. Patients with this mutation appear to have a predisposition for myocardial infarction."xsd:string |
| http://purl.uniprot.org/citations/15131548 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ahj.2003.10.048"xsd:string |
| http://purl.uniprot.org/citations/15131548 | http://purl.uniprot.org/core/author | "Seidel D."xsd:string |
| http://purl.uniprot.org/citations/15131548 | http://purl.uniprot.org/core/author | "Steinbeck G."xsd:string |
| http://purl.uniprot.org/citations/15131548 | http://purl.uniprot.org/core/author | "Gohring P."xsd:string |
| http://purl.uniprot.org/citations/15131548 | http://purl.uniprot.org/core/author | "Huehns T.Y."xsd:string |
| http://purl.uniprot.org/citations/15131548 | http://purl.uniprot.org/core/author | "Middendorf K."xsd:string |
| http://purl.uniprot.org/citations/15131548 | http://purl.uniprot.org/core/author | "Nikol S."xsd:string |
| http://purl.uniprot.org/citations/15131548 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15131548 | http://purl.uniprot.org/core/name | "Am Heart J"xsd:string |
| http://purl.uniprot.org/citations/15131548 | http://purl.uniprot.org/core/pages | "897-904"xsd:string |
| http://purl.uniprot.org/citations/15131548 | http://purl.uniprot.org/core/title | "Prevalence of resistance against activated protein C resulting from factor V Leiden is significantly increased in myocardial infarction: investigation of 507 patients with myocardial infarction."xsd:string |
| http://purl.uniprot.org/citations/15131548 | http://purl.uniprot.org/core/volume | "147"xsd:string |
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