| http://purl.uniprot.org/citations/15132976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15132976 | http://www.w3.org/2000/01/rdf-schema#comment | "Mice deficient in the smooth muscle Cav1.2 calcium channel (SMACKO, smooth muscle alpha1c-subunit calcium channel knockout) have a severely reduced micturition and an increased bladder mass. L-type calcium current, protein, and spontaneous contractile activity were absent in the bladder of SMACKO mice. K+ and carbachol (CCh)-induced contractions were reduced to 10-fold in detrusor muscles from SMACKO mice. The dihydropyridine isradipine inhibited K+- and CCh-induced contractions of muscles from CTR but had no effect in muscles from SMACKO mice. CCh-induced contraction was blocked by removing extracellular Ca2+ but was unaffected by the PLC inhibitor U73122 or depletion of intracellular Ca2+ stores by thapsigargin. In muscles from CTR and SMACKO mice, CCh-induced contraction was partially inhibited by the Rho-kinase inhibitor Y27632. These results show that the Cav1.2 Ca2+ channel is essential for normal bladder function. The Rho-kinase and Ca2+-release pathways cannot compensate the lack of the L-type Ca2+ channel."xsd:string |
| http://purl.uniprot.org/citations/15132976 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.04-1516fje"xsd:string |
| http://purl.uniprot.org/citations/15132976 | http://purl.uniprot.org/core/author | "Klugbauer N."xsd:string |
| http://purl.uniprot.org/citations/15132976 | http://purl.uniprot.org/core/author | "Feil R."xsd:string |
| http://purl.uniprot.org/citations/15132976 | http://purl.uniprot.org/core/author | "Hofmann F."xsd:string |
| http://purl.uniprot.org/citations/15132976 | http://purl.uniprot.org/core/author | "Koller A."xsd:string |
| http://purl.uniprot.org/citations/15132976 | http://purl.uniprot.org/core/author | "Feil S."xsd:string |
| http://purl.uniprot.org/citations/15132976 | http://purl.uniprot.org/core/author | "Moosmang S."xsd:string |
| http://purl.uniprot.org/citations/15132976 | http://purl.uniprot.org/core/author | "Schulla V."xsd:string |
| http://purl.uniprot.org/citations/15132976 | http://purl.uniprot.org/core/author | "Wegener J.W."xsd:string |
| http://purl.uniprot.org/citations/15132976 | http://purl.uniprot.org/core/author | "Welling A."xsd:string |
| http://purl.uniprot.org/citations/15132976 | http://purl.uniprot.org/core/author | "Lee T.S."xsd:string |
| http://purl.uniprot.org/citations/15132976 | http://purl.uniprot.org/core/author | "Kleppisch T."xsd:string |
| http://purl.uniprot.org/citations/15132976 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15132976 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/15132976 | http://purl.uniprot.org/core/pages | "1159-1161"xsd:string |
| http://purl.uniprot.org/citations/15132976 | http://purl.uniprot.org/core/title | "An essential role of Cav1.2 L-type calcium channel for urinary bladder function."xsd:string |
| http://purl.uniprot.org/citations/15132976 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/15132976 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15132976 |
| http://purl.uniprot.org/citations/15132976 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15132976 |
| http://purl.uniprot.org/uniprot/Q01815#attribution-60382A1A2681E17D3134F0DD566ECA8B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15132976 |
| http://purl.uniprot.org/uniprot/Q01815#attribution-CCCD818A99F857BAB8A1571701BEAE88 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15132976 |
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| http://purl.uniprot.org/uniprot/#_A0A087WPZ8-mappedCitation-15132976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15132976 |