| http://purl.uniprot.org/citations/15132993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15132993 | http://www.w3.org/2000/01/rdf-schema#comment | "The regulation of telomerase action, and its coordination with conventional DNA replication and chromosome end "capping," are still poorly understood. Here we describe a genetic screen in yeast for mutants with relaxed telomere length regulation, and the identification of Pol12, the B subunit of the DNA polymerase alpha (Pol1)-primase complex, as a new factor involved in this process. Unlike many POL1 and POL12 mutations, which also cause telomere elongation, the pol12-216 mutation described here does not lead to either reduced Pol1 function, increased telomeric single-stranded DNA, or a reduction in telomeric gene silencing. Instead, and again unlike mutations affecting POL1, pol12-216 is lethal in combination with a mutation in the telomere end-binding and capping protein Stn1. Significantly, Pol12 and Stn1 interact in both two-hybrid and biochemical assays, and their synthetic-lethal interaction appears to be caused, at least in part, by a loss of telomere capping. These data reveal a novel function for Pol12 and a new connection between DNA polymerase alpha and Stn1. We propose that Pol12, together with Stn1, plays a key role in linking telomerase action with the completion of lagging strand synthesis, and in a regulatory step required for telomere capping."xsd:string |
| http://purl.uniprot.org/citations/15132993 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.300004"xsd:string |
| http://purl.uniprot.org/citations/15132993 | http://purl.uniprot.org/core/author | "Grossi S."xsd:string |
| http://purl.uniprot.org/citations/15132993 | http://purl.uniprot.org/core/author | "Lopes M."xsd:string |
| http://purl.uniprot.org/citations/15132993 | http://purl.uniprot.org/core/author | "Shore D."xsd:string |
| http://purl.uniprot.org/citations/15132993 | http://purl.uniprot.org/core/author | "Dmitriev P.V."xsd:string |
| http://purl.uniprot.org/citations/15132993 | http://purl.uniprot.org/core/author | "Puglisi A."xsd:string |
| http://purl.uniprot.org/citations/15132993 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15132993 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/15132993 | http://purl.uniprot.org/core/pages | "992-1006"xsd:string |
| http://purl.uniprot.org/citations/15132993 | http://purl.uniprot.org/core/title | "Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation."xsd:string |
| http://purl.uniprot.org/citations/15132993 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/15132993 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15132993 |
| http://purl.uniprot.org/citations/15132993 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15132993 |
| http://purl.uniprot.org/uniprot/P38121#attribution-840BA40BC64183A2DA21191FDB391D36 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15132993 |
| http://purl.uniprot.org/uniprot/P38960#attribution-840BA40BC64183A2DA21191FDB391D36 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15132993 |
| http://purl.uniprot.org/uniprot/#_P38960-mappedCitation-15132993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15132993 |
| http://purl.uniprot.org/uniprot/#_P38121-mappedCitation-15132993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15132993 |
| http://purl.uniprot.org/uniprot/P38960 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15132993 |
| http://purl.uniprot.org/uniprot/P38121 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15132993 |