| http://purl.uniprot.org/citations/15138281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15138281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15138281 | http://www.w3.org/2000/01/rdf-schema#comment | "Clustering of the T cell integrin, LFA-1, at specialized regions of intercellular contact initiates integrin-mediated adhesion and downstream signaling, events that are necessary for a successful immunological response. But how clustering is achieved and sustained is not known. Here we establish that an LFA-1-associated molecule, PTA-1, is localized to membrane rafts and binds the carboxyl-terminal domain of isoforms of the actin-binding protein 4.1G. Protein 4.1 is known to associate with the membrane-associated guanylate kinase homologue, human discs large. We show that the carboxyl-terminal peptide of PTA-1 also can bind human discs large and that the presence or absence of this peptide greatly influences binding between PTA-1 and different isoforms of 4.1G. T cell stimulation with phorbol ester or PTA-1 cross-linking induces PTA-1 and 4.1G to associate tightly with the cytoskeleton, and the PTA-1 from such activated cells now can bind to the amino-terminal region of 4.1G. We propose that these dynamic associations provide the structural basis for a regulated molecular adhesive complex that serves to cluster and transport LFA-1 and associated molecules."xsd:string |
| http://purl.uniprot.org/citations/15138281 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.M401040200"xsd:string |
| http://purl.uniprot.org/citations/15138281 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m401040200"xsd:string |
| http://purl.uniprot.org/citations/15138281 | http://purl.uniprot.org/core/author | "Berndt M.C."xsd:string |
| http://purl.uniprot.org/citations/15138281 | http://purl.uniprot.org/core/author | "Berndt M.C."xsd:string |
| http://purl.uniprot.org/citations/15138281 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/15138281 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/15138281 | http://purl.uniprot.org/core/author | "Scott J.L."xsd:string |
| http://purl.uniprot.org/citations/15138281 | http://purl.uniprot.org/core/author | "Scott J.L."xsd:string |
| http://purl.uniprot.org/citations/15138281 | http://purl.uniprot.org/core/author | "Jin B."xsd:string |
| http://purl.uniprot.org/citations/15138281 | http://purl.uniprot.org/core/author | "Jin B."xsd:string |
| http://purl.uniprot.org/citations/15138281 | http://purl.uniprot.org/core/author | "Burns G.F."xsd:string |
| http://purl.uniprot.org/citations/15138281 | http://purl.uniprot.org/core/author | "Burns G.F."xsd:string |
| http://purl.uniprot.org/citations/15138281 | http://purl.uniprot.org/core/author | "Boyd A.W."xsd:string |
| http://purl.uniprot.org/citations/15138281 | http://purl.uniprot.org/core/author | "Boyd A.W."xsd:string |
| http://purl.uniprot.org/citations/15138281 | http://purl.uniprot.org/core/author | "Thorne R.F."xsd:string |
| http://purl.uniprot.org/citations/15138281 | http://purl.uniprot.org/core/author | "Thorne R.F."xsd:string |
| http://purl.uniprot.org/citations/15138281 | http://purl.uniprot.org/core/author | "Hird S.L."xsd:string |
| http://purl.uniprot.org/citations/15138281 | http://purl.uniprot.org/core/author | "Hird S.L."xsd:string |
| http://purl.uniprot.org/citations/15138281 | http://purl.uniprot.org/core/author | "Ralston K.J."xsd:string |
| http://purl.uniprot.org/citations/15138281 | http://purl.uniprot.org/core/author | "Ralston K.J."xsd:string |
| http://purl.uniprot.org/citations/15138281 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15138281 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |