| http://purl.uniprot.org/citations/15140220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15140220 | http://www.w3.org/2000/01/rdf-schema#comment | "TNF-like weak inducer of apoptosis (TWEAK), a member of the tumor necrosis factor (TNF) family, is a multifunctional cytokine that regulate cellular proliferation, angiogenesis, inflammation, and apoptosis. In this study, we investigated the effect of TWEAK on human keratinocytes. Primary cultured normal human keratinocytes constitutively expressed a TWEAK receptor, fibroblast growth factor-inducible 14 (Fn14), and produced regulated on activation, normal T expressed and secreted (RANTES) upon TWEAK stimulation in a concentration-dependent manner. The TWEAK-induced RANTES production was abrogated by anti-Fn14 antibody, and synergistically augmented by simultaneous stimulation with transforming growth factor-beta. In addition, human keratinocytes differentiated in vitro with high Ca(2+)-containing medium showed enhanced production of RANTES upon TWEAK stimulation. Furthermore, TWEAK induced rapid phosphorylation of IkappaB-alpha in human keratinocytes. Collectively, TWEAK acts on human keratinocytes as an inducer of RANTES via Fn14. Because RANTES has been implicated in inflammation, TWEAK/Fn14 interaction in human keratinocytes may be involved in the pathophysiology of inflammatory skin disorders."xsd:string |
| http://purl.uniprot.org/citations/15140220 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.0022-202x.2004.22419.x"xsd:string |
| http://purl.uniprot.org/citations/15140220 | http://purl.uniprot.org/core/author | "Jin L."xsd:string |
| http://purl.uniprot.org/citations/15140220 | http://purl.uniprot.org/core/author | "Nakayama M."xsd:string |
| http://purl.uniprot.org/citations/15140220 | http://purl.uniprot.org/core/author | "Ogawa H."xsd:string |
| http://purl.uniprot.org/citations/15140220 | http://purl.uniprot.org/core/author | "Nakano N."xsd:string |
| http://purl.uniprot.org/citations/15140220 | http://purl.uniprot.org/core/author | "Okumura K."xsd:string |
| http://purl.uniprot.org/citations/15140220 | http://purl.uniprot.org/core/author | "Kojima Y."xsd:string |
| http://purl.uniprot.org/citations/15140220 | http://purl.uniprot.org/core/author | "Yamaguchi N."xsd:string |
| http://purl.uniprot.org/citations/15140220 | http://purl.uniprot.org/core/author | "Nakao A."xsd:string |
| http://purl.uniprot.org/citations/15140220 | http://purl.uniprot.org/core/author | "Yagita H."xsd:string |
| http://purl.uniprot.org/citations/15140220 | http://purl.uniprot.org/core/author | "Tsuboi R."xsd:string |
| http://purl.uniprot.org/citations/15140220 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15140220 | http://purl.uniprot.org/core/name | "J Invest Dermatol"xsd:string |
| http://purl.uniprot.org/citations/15140220 | http://purl.uniprot.org/core/pages | "1175-1179"xsd:string |
| http://purl.uniprot.org/citations/15140220 | http://purl.uniprot.org/core/title | "Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes."xsd:string |
| http://purl.uniprot.org/citations/15140220 | http://purl.uniprot.org/core/volume | "122"xsd:string |
| http://purl.uniprot.org/citations/15140220 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15140220 |
| http://purl.uniprot.org/citations/15140220 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15140220 |
| http://purl.uniprot.org/uniprot/#_D0EI67-mappedCitation-15140220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15140220 |
| http://purl.uniprot.org/uniprot/#_A0A0U5J5F5-mappedCitation-15140220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15140220 |
| http://purl.uniprot.org/uniprot/#_A0A494C1Q1-mappedCitation-15140220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15140220 |
| http://purl.uniprot.org/uniprot/#_B2R5J8-mappedCitation-15140220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15140220 |
| http://purl.uniprot.org/uniprot/#_C0H5Y4-mappedCitation-15140220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15140220 |