http://purl.uniprot.org/citations/15144476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/15144476 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundOrganic acid anhydrides are low molecular weight industrial chemicals, able to cause rhinoconjunctivitis and asthma associated with specific IgE against hapten-carrier protein conjugate. Only a proportion of exposed workers develop IgE-associated allergy to acid anhydrides.ObjectiveWe determined whether genetic susceptibility, in particular, HLA Class II alleles may be a risk factor.MethodsWe undertook HLA typing in 52 cases who had confirmed specific IgE and in 73 referents matched on site, age and duration of acid anhydride exposure identified in cross-sectional studies of workers exposed to hexahydrophthalic (HHPA), methylhexahydrophthalic (MHHPA) and methyltetrahydrophthalic (MTHPA) anhydrides.ResultsThe linked alleles DQ5 (odds ratio [OR]=4.3; 95% confidence interval [95% CI]=1.7, 11) and DR1 (OR 3.0; 95% CI 1.2, 11) were more prevalent in cases than in referents. Within DQ5, DQB1(*)0501 was particularly frequent (OR 3.0; 95% CI 1.2, 7.4).ConclusionDQB1(*)05 gene confers susceptibility to develop specific IgE antibodies against HHPA, MHHPA and a non-significant trend with MTHPA. DQB1(*)0501 is protective for other low molecular chemical sensitizers (isocyanates and plicatic acid) which may indicate varying affinities for the corresponding specific class II molecules."xsd:string |
http://purl.uniprot.org/citations/15144476 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2222.2004.1956.x"xsd:string |
http://purl.uniprot.org/citations/15144476 | http://purl.uniprot.org/core/author | "Nielsen J."xsd:string |
http://purl.uniprot.org/citations/15144476 | http://purl.uniprot.org/core/author | "Harris J."xsd:string |
http://purl.uniprot.org/citations/15144476 | http://purl.uniprot.org/core/author | "Welsh K."xsd:string |
http://purl.uniprot.org/citations/15144476 | http://purl.uniprot.org/core/author | "Welch J."xsd:string |
http://purl.uniprot.org/citations/15144476 | http://purl.uniprot.org/core/author | "Jones M.G."xsd:string |
http://purl.uniprot.org/citations/15144476 | http://purl.uniprot.org/core/author | "Taylor A.N."xsd:string |
http://purl.uniprot.org/citations/15144476 | http://purl.uniprot.org/core/author | "Bensryd I."xsd:string |
http://purl.uniprot.org/citations/15144476 | http://purl.uniprot.org/core/author | "Skerfving S."xsd:string |
http://purl.uniprot.org/citations/15144476 | http://purl.uniprot.org/core/author | "Venables K.M."xsd:string |
http://purl.uniprot.org/citations/15144476 | http://purl.uniprot.org/core/author | "Welinder H."xsd:string |
http://purl.uniprot.org/citations/15144476 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
http://purl.uniprot.org/citations/15144476 | http://purl.uniprot.org/core/name | "Clin Exp Allergy"xsd:string |
http://purl.uniprot.org/citations/15144476 | http://purl.uniprot.org/core/pages | "812-816"xsd:string |
http://purl.uniprot.org/citations/15144476 | http://purl.uniprot.org/core/title | "Association of HLA-DQ5 and HLA-DR1 with sensitization to organic acid anhydrides."xsd:string |
http://purl.uniprot.org/citations/15144476 | http://purl.uniprot.org/core/volume | "34"xsd:string |
http://purl.uniprot.org/citations/15144476 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15144476 |
http://purl.uniprot.org/citations/15144476 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15144476 |
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