| http://purl.uniprot.org/citations/15147729 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15147729 | http://www.w3.org/2000/01/rdf-schema#comment | "A3 adenosine receptor agonists have been reported to influence cell death and survival. Here we report the effects of an A3 adenosine receptor agonist, IB-MECA, on the cell growth of human breast cancer cell lines, MCF-7 (estrogen receptor positive) and MDA-MB468 (estrogen receptor negative). Therefore, this study was aimed to investigate the expression and possible action of A3 receptor in the human breast cancer cell lines. IB-MECA, at 1-100 microM, resulted in a significant cell growth inhibition (P < 0.05) which reached the maximum at 48 h, in the cell lines. In both cell lines, agonist-induced effects were antagonized by pretreatment with a selective A3 adenosine receptor antagonist, MRS1220. Using RT-PCR method, further confirmation was provided by the presence of mRNA of A3 receptor in the cells. In addition, IB-MECA was able to inhibit forskolin-stimulated cAMP levels, which indicate the functional form of A3 receptor on the cell surface of these breast cancer cell lines. These results suggest that the inhibitory effect of IB-MECA on the growth of human breast cancer cell lines is mediated through activation of A3 adenosine receptor."xsd:string |
| http://purl.uniprot.org/citations/15147729 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biocel.2003.12.001"xsd:string |
| http://purl.uniprot.org/citations/15147729 | http://purl.uniprot.org/core/author | "Karami-Tehrani F."xsd:string |
| http://purl.uniprot.org/citations/15147729 | http://purl.uniprot.org/core/author | "Panjehpour M."xsd:string |
| http://purl.uniprot.org/citations/15147729 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15147729 | http://purl.uniprot.org/core/name | "Int J Biochem Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/15147729 | http://purl.uniprot.org/core/pages | "1502-1509"xsd:string |
| http://purl.uniprot.org/citations/15147729 | http://purl.uniprot.org/core/title | "An adenosine analog (IB-MECA) inhibits anchorage-dependent cell growth of various human breast cancer cell lines."xsd:string |
| http://purl.uniprot.org/citations/15147729 | http://purl.uniprot.org/core/volume | "36"xsd:string |
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