RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/15148409http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15148409http://www.w3.org/2000/01/rdf-schema#comment"Inhibitor of beta-catenin and T cell factor (ICAT) inhibits Wnt signaling by interfering with the interaction between beta-catenin and T cell factor. Here we show that ICAT(-/-) embryos exhibit malformation of the forebrain and craniofacial bones and lack the kidney. Analysis of the neuronal differentiation of embryonic stem cells revealed that Wnt3a redirects the fate of neural progenitors to a posterior character, whereas ICAT induces forebrain cells by inhibiting Wnt signaling. Furthermore, ICAT(-/-) embryonic stem cells were found to differentiate into neuronal cells possessing a posterior character. These results suggest that ICAT plays an important role in the anteriorization of neural cells by inhibiting the posteriorizing activity of Wnt signaling."xsd:string
http://purl.uniprot.org/citations/15148409http://purl.org/dc/terms/identifier"doi:10.1073/pnas.0401733101"xsd:string
http://purl.uniprot.org/citations/15148409http://purl.uniprot.org/core/author"Hasegawa Y."xsd:string
http://purl.uniprot.org/citations/15148409http://purl.uniprot.org/core/author"Nakamura T."xsd:string
http://purl.uniprot.org/citations/15148409http://purl.uniprot.org/core/author"Satoh K."xsd:string
http://purl.uniprot.org/citations/15148409http://purl.uniprot.org/core/author"Senda T."xsd:string
http://purl.uniprot.org/citations/15148409http://purl.uniprot.org/core/author"Takada S."xsd:string
http://purl.uniprot.org/citations/15148409http://purl.uniprot.org/core/author"Akiyama T."xsd:string
http://purl.uniprot.org/citations/15148409http://purl.uniprot.org/core/author"Nada S."xsd:string
http://purl.uniprot.org/citations/15148409http://purl.uniprot.org/core/author"Kasai M."xsd:string
http://purl.uniprot.org/citations/15148409http://purl.uniprot.org/core/author"Tago K."xsd:string
http://purl.uniprot.org/citations/15148409http://purl.uniprot.org/core/author"Ohwada S."xsd:string
http://purl.uniprot.org/citations/15148409http://purl.uniprot.org/core/author"Ishidao T."xsd:string
http://purl.uniprot.org/citations/15148409http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15148409http://purl.uniprot.org/core/name"Proc Natl Acad Sci U S A"xsd:string
http://purl.uniprot.org/citations/15148409http://purl.uniprot.org/core/pages"8017-8021"xsd:string
http://purl.uniprot.org/citations/15148409http://purl.uniprot.org/core/title"Anteriorization of neural fate by inhibitor of beta-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling."xsd:string
http://purl.uniprot.org/citations/15148409http://purl.uniprot.org/core/volume"101"xsd:string
http://purl.uniprot.org/citations/15148409http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15148409
http://purl.uniprot.org/citations/15148409http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15148409
http://purl.uniprot.org/uniprot/Q9JJN6#attribution-418C378684719DE7427FF005A8404AC0http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/15148409
http://purl.uniprot.org/uniprot/Q9JJN6#attribution-CF782D041DEA5890C84B47009FDCCFDAhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/15148409
http://purl.uniprot.org/uniprot/P27467#attribution-418C378684719DE7427FF005A8404AC0http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/15148409
http://purl.uniprot.org/uniprot/#_A0A1D5RM76-mappedCitation-15148409http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15148409