| http://purl.uniprot.org/citations/15151997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15151997 | http://www.w3.org/2000/01/rdf-schema#comment | "The constitutive androstane receptor (CAR) is an interesting member of the nuclear receptor superfamily because of its exceptionally high constitutive activity due to ligand-independent interaction of the ligand-binding domain with co-activator proteins. This study compares the agonist-dependent and agonist-independent activities of human CAR with those of mouse CAR and the vitamin D receptor and demonstrates that the constitutive activity of CAR is mediated by at least three contacts between the amino acids of helix 12, partner amino acids in helices 4 and 11, and a charge clamp between helices 12 and 3. The stabilization of helix 12 by a contact between its C terminus and the lysine of helix 4 has the same impact in human and mouse CARs. In addition, the charge clamp between the glutamate in helix 12 and the lysine in helix 3 is also important for the constitutive activity of both receptor orthologs but less critical for the agonist-dependent stabilization of their respective helices 12. Interestingly, Cys-357 in mouse CAR has significantly more impact on the stabilization of helix 12 than does the orthologous position Cys-347 in human CAR. This deficit appears to be compensated by a more dominant role of Ile-330 in human CAR over Leu-340 in mouse CAR because it is more efficient than Cys-347 in controlling the flexibility of helix 12 in the presence of an agonist. The constitutive activity of other members of the nuclear receptor superfamily could be explained by a homologous hydrophobic interaction between large, non-polar amino acids of helices 11 and 12."xsd:string |
| http://purl.uniprot.org/citations/15151997 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m403946200"xsd:string |
| http://purl.uniprot.org/citations/15151997 | http://purl.uniprot.org/core/author | "Lempiainen H."xsd:string |
| http://purl.uniprot.org/citations/15151997 | http://purl.uniprot.org/core/author | "Frank C."xsd:string |
| http://purl.uniprot.org/citations/15151997 | http://purl.uniprot.org/core/author | "Carlberg C."xsd:string |
| http://purl.uniprot.org/citations/15151997 | http://purl.uniprot.org/core/author | "Matilainen M."xsd:string |
| http://purl.uniprot.org/citations/15151997 | http://purl.uniprot.org/core/author | "Molnar F."xsd:string |
| http://purl.uniprot.org/citations/15151997 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15151997 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15151997 | http://purl.uniprot.org/core/pages | "33558-33566"xsd:string |
| http://purl.uniprot.org/citations/15151997 | http://purl.uniprot.org/core/title | "Agonist-dependent and agonist-independent transactivations of the human constitutive androstane receptor are modulated by specific amino acid pairs."xsd:string |
| http://purl.uniprot.org/citations/15151997 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/15151997 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15151997 |
| http://purl.uniprot.org/citations/15151997 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15151997 |
| http://purl.uniprot.org/uniprot/#_C0H5Y2-mappedCitation-15151997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15151997 |
| http://purl.uniprot.org/uniprot/#_B6ZGT2-mappedCitation-15151997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15151997 |
| http://purl.uniprot.org/uniprot/#_B7Z8Q3-mappedCitation-15151997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15151997 |
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| http://purl.uniprot.org/uniprot/#_O35627-mappedCitation-15151997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15151997 |
| http://purl.uniprot.org/uniprot/#_Q3UEP1-mappedCitation-15151997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15151997 |
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| http://purl.uniprot.org/uniprot/#_Q6GZ69-mappedCitation-15151997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15151997 |