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http://purl.uniprot.org/citations/15157381http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15157381http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Narcolepsy is a lifelong sleep disorder characterized by excessive daytime sleepiness, and features of rapid eye movement (REM) sleep, such as cataplexy, sleep paralysis and hypnagogic hallucinations. The present study aimed to investigate the diagnostic basis of childhood narcolepsy and possible role of HLA Class II alleles in the onset of this disease.

Methods

The clinical data of 40 narcoleptic children were analyzed. All patients received Multiple Sleep Latency Test (MSLT) and they were analyzed in combination with clinical features. Polymerase chain reaction/sequence specific primers (PCR/SSP) methods were used to detect the HLA-DRB1 and DQB1 alleles.

Results

Narcolepsy was diagnosed in 40 children. The age range was 3 to 14 years (mean 8.5 +/-2.5 years), 29 were male and 11 female. Their mean course of disease was 6.5 months, 14 patients (30%) were less than 3 months old, 21 patients (52%) were less than 6 months old. All the patients had excessive daytime sleepiness, cataplexy appeared in 37 cases, hypnagogic hallucination in 22 and sleep paralysis in 6. Mean sleep latency on MSLT was less than 5 min, the average number of sleep-onset rapid eye movement (SOREM) was 4.33 +/-0.26 episodes (2-5 episodes), the latency of SOREM episodes were 4.0 +/-1.8 min (0.25-4.9 min). Thirty-five patients were DRB1 1501 and DQB1 0602 positive (Pc < 0.01), 2 were DRB1 1502 and DQB1 0601 positive, while 3 were DRB1 15 and DQB1 6 negative.

Conclusions

Some pediatric patients with narcolepsy were different from adult patients in that the pediatric cases had a sudden onset and shorter disease course. Diagnosis of this disease was based on the clinical manifestations, MSLT and absence of any medical or psychiatric disorder that could account for the symptoms. The authors demonstrated that DRB1 1501 and DQB1 0602 were susceptibility genes for narcolepsy and those who were DRB1 15 negative could not be excluded."xsd:string
http://purl.uniprot.org/citations/15157381http://purl.uniprot.org/core/author"Chen C.H."xsd:string
http://purl.uniprot.org/citations/15157381http://purl.uniprot.org/core/author"Han F."xsd:string
http://purl.uniprot.org/citations/15157381http://purl.uniprot.org/core/author"Fang F."xsd:string
http://purl.uniprot.org/citations/15157381http://purl.uniprot.org/core/author"Li J."xsd:string
http://purl.uniprot.org/citations/15157381http://purl.uniprot.org/core/author"Xiao J."xsd:string
http://purl.uniprot.org/citations/15157381http://purl.uniprot.org/core/author"Zhang W.C."xsd:string
http://purl.uniprot.org/citations/15157381http://purl.uniprot.org/core/author"Guo Y.H."xsd:string
http://purl.uniprot.org/citations/15157381http://purl.uniprot.org/core/author"Wu H.S."xsd:string
http://purl.uniprot.org/citations/15157381http://purl.uniprot.org/core/author"Zou L.P."xsd:string
http://purl.uniprot.org/citations/15157381http://purl.uniprot.org/core/author"Ding C.H."xsd:string
http://purl.uniprot.org/citations/15157381http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15157381http://purl.uniprot.org/core/name"Zhonghua Er Ke Za Zhi"xsd:string
http://purl.uniprot.org/citations/15157381http://purl.uniprot.org/core/pages"248-251"xsd:string
http://purl.uniprot.org/citations/15157381http://purl.uniprot.org/core/title"[Diagnosis of childhood narcolepsy and significance of HLA in its diagnosis]."xsd:string
http://purl.uniprot.org/citations/15157381http://purl.uniprot.org/core/volume"42"xsd:string
http://purl.uniprot.org/citations/15157381http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15157381
http://purl.uniprot.org/citations/15157381http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15157381
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-15157381http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15157381
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-15157381http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15157381
http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-15157381http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15157381
http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-15157381http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15157381
http://purl.uniprot.org/uniprot/#_A0A0E3DC99-mappedCitation-15157381http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15157381
http://purl.uniprot.org/uniprot/#_A0A076L4M5-mappedCitation-15157381http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15157381
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