| http://purl.uniprot.org/citations/15157420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15157420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15157420 | http://www.w3.org/2000/01/rdf-schema#comment | "G protein-coupled receptors (GPCRs) mediate diverse signaling processes, including olfaction. G protein-coupled receptor kinases (GRKs) are important regulators of G protein signal transduction that specifically phosphorylate activated GPCRs to terminate signaling. Despite previously described roles for GRKs in GPCR signal downregulation, animals lacking C. elegans G protein-coupled receptor kinase-2 (Ce-grk-2) function are not hypersensitive to odorants. Instead, decreased Ce-grk-2 function in adult sensory neurons profoundly disrupts chemosensation, based on both behavioral analysis and Ca(2+) imaging. Although mammalian arrestin proteins cooperate with GRKs in receptor desensitization, loss of C. elegans arrestin-1 (arr-1) does not disrupt chemosensation. Either overexpression of the C. elegans Galpha subunit odr-3 or loss of eat-16, which encodes a regulator of G protein signaling (RGS) protein, restores chemosensation in Ce-grk-2 mutants. These results demonstrate that loss of GRK function can lead to reduced GPCR signal transduction and suggest an important role for RGS proteins in the regulation of chemosensation."xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(04)00252-1"xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(04)00252-1"xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.uniprot.org/core/author | "Lefkowitz R.J."xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.uniprot.org/core/author | "Lefkowitz R.J."xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.uniprot.org/core/author | "Jansen G."xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.uniprot.org/core/author | "Jansen G."xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.uniprot.org/core/author | "Schafer W.R."xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.uniprot.org/core/author | "Schafer W.R."xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.uniprot.org/core/author | "Apicella A.J."xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.uniprot.org/core/author | "Apicella A.J."xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.uniprot.org/core/author | "Ferkey D.M."xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.uniprot.org/core/author | "Ferkey D.M."xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.uniprot.org/core/author | "Fukuto H.S."xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.uniprot.org/core/author | "Fukuto H.S."xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.uniprot.org/core/author | "Hart A.C."xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.uniprot.org/core/author | "Hart A.C."xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.uniprot.org/core/author | "Lans H."xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.uniprot.org/core/author | "Lans H."xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.uniprot.org/core/author | "Sharmeen T."xsd:string |
| http://purl.uniprot.org/citations/15157420 | http://purl.uniprot.org/core/author | "Sharmeen T."xsd:string |