| http://purl.uniprot.org/citations/15158472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15158472 | http://www.w3.org/2000/01/rdf-schema#comment | "Bone morphogenetic proteins (BMPs) play central roles in differentiation, development, and physiologic tissue remodeling. Recently, we have demonstrated that a protein inhibitor of activated STAT, PIASy, suppresses TGF-beta signaling by interacting with Sma and MAD-related protein 3 (Smad3). In this study, we examined a PIASy-dependent inhibitory effect on BMP signaling. PIASy expression was induced by BMP-2 stimulation and suppressed BMP-2-dependent Smad activity in hepatoma cells. Furthermore, BMP-2-regulated Smads directly bound to PIASy. We also demonstrated that the RING domain of PIASy played an important role in PIASy-mediated suppression of Smad activity. We here provide evidence that the inhibitory action of PIASy on BMP-regulated Smad activity was due to direct physical interactions between Smads and PIASy through its RING domain."xsd:string |
| http://purl.uniprot.org/citations/15158472 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2004.04.161"xsd:string |
| http://purl.uniprot.org/citations/15158472 | http://purl.uniprot.org/core/author | "Sugiyama K."xsd:string |
| http://purl.uniprot.org/citations/15158472 | http://purl.uniprot.org/core/author | "Yamamoto T."xsd:string |
| http://purl.uniprot.org/citations/15158472 | http://purl.uniprot.org/core/author | "Matsuda T."xsd:string |
| http://purl.uniprot.org/citations/15158472 | http://purl.uniprot.org/core/author | "Imoto S."xsd:string |
| http://purl.uniprot.org/citations/15158472 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15158472 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/15158472 | http://purl.uniprot.org/core/pages | "275-282"xsd:string |
| http://purl.uniprot.org/citations/15158472 | http://purl.uniprot.org/core/title | "The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/15158472 | http://purl.uniprot.org/core/volume | "319"xsd:string |
| http://purl.uniprot.org/citations/15158472 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15158472 |
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| http://purl.uniprot.org/uniprot/#_Q53H55-mappedCitation-15158472 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15158472 |
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