| http://purl.uniprot.org/citations/15159397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15159397 | http://www.w3.org/2000/01/rdf-schema#comment | "BRCA1 is a major player in the DNA damage response. This is evident from its loss, which causes cells to become sensitive to a wide variety of DNA damaging agents. The major BRCA1 binding partner, BARD1, is also implicated in the DNA damage response, and recent reports indicate that BRCA1 and BARD1 co-operate in this pathway. In this report, we utilized small interfering RNA to deplete BRCA1 and BARD1 to demonstrate that the BRCA1-BARD1 complex is required for ATM/ATR (ataxia-telangiectasia-mutated/ATM and Rad3-related)-mediated phosphorylation of p53(Ser-15) following IR- and UV radiation-induced DNA damage. In contrast, phosphorylation of a number of other ATM/ATR targets including H2AX, Chk2, Chk1, and c-jun does not depend on the presence of BRCA1-BARD1 complexes. Moreover, prior ATM/ATR-dependent phosphorylation of BRCA1 at Ser-1423 or Ser-1524 regulates the ability of ATM/ATR to phosphorylate p53(Ser-15) efficiently. Phosphorylation of p53(Ser-15) is necessary for an IR-induced G(1)/S arrest via transcriptional induction of the cyclin-dependent kinase inhibitor p21. Consistent with these data, repressing p53(Ser-15) phosphorylation by BRCA1-BARD1 depletion compromises p21 induction and the G(1)/S checkpoint arrest in response to IR but not UV radia-tion. These findings suggest that BRCA1-BARD1 complexes act as an adaptor to mediate ATM/ATR-directed phosphorylation of p53, influencing G(1)/S cell cycle progression after DNA damage."xsd:string |
| http://purl.uniprot.org/citations/15159397 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m405372200"xsd:string |
| http://purl.uniprot.org/citations/15159397 | http://purl.uniprot.org/core/author | "Hobson K."xsd:string |
| http://purl.uniprot.org/citations/15159397 | http://purl.uniprot.org/core/author | "Khanna K.K."xsd:string |
| http://purl.uniprot.org/citations/15159397 | http://purl.uniprot.org/core/author | "Savage K."xsd:string |
| http://purl.uniprot.org/citations/15159397 | http://purl.uniprot.org/core/author | "Fabbro M."xsd:string |
| http://purl.uniprot.org/citations/15159397 | http://purl.uniprot.org/core/author | "Deans A.J."xsd:string |
| http://purl.uniprot.org/citations/15159397 | http://purl.uniprot.org/core/author | "Powell S.N."xsd:string |
| http://purl.uniprot.org/citations/15159397 | http://purl.uniprot.org/core/author | "McArthur G.A."xsd:string |
| http://purl.uniprot.org/citations/15159397 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15159397 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15159397 | http://purl.uniprot.org/core/pages | "31251-31258"xsd:string |
| http://purl.uniprot.org/citations/15159397 | http://purl.uniprot.org/core/title | "BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage."xsd:string |
| http://purl.uniprot.org/citations/15159397 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/15159397 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15159397 |
| http://purl.uniprot.org/citations/15159397 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15159397 |
| http://purl.uniprot.org/uniprot/P38398#attribution-25EDECDFC8E11C4BA15DA7A17F2E2B1F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15159397 |
| http://purl.uniprot.org/uniprot/P48754#attribution-25EDECDFC8E11C4BA15DA7A17F2E2B1F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15159397 |
| http://purl.uniprot.org/uniprot/Q99728#attribution-25EDECDFC8E11C4BA15DA7A17F2E2B1F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15159397 |
| http://purl.uniprot.org/uniprot/O70445#attribution-25EDECDFC8E11C4BA15DA7A17F2E2B1F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15159397 |
| http://purl.uniprot.org/uniprot/#_A0A087WP26-mappedCitation-15159397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15159397 |
| http://purl.uniprot.org/uniprot/#_A0A087WPE1-mappedCitation-15159397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15159397 |
| http://purl.uniprot.org/uniprot/#_A0A087WPK5-mappedCitation-15159397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15159397 |
| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-15159397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15159397 |