| http://purl.uniprot.org/citations/15159416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15159416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15159416 | http://www.w3.org/2000/01/rdf-schema#comment | "Cofilin mediates lamellipodium extension and polarized cell migration by stimulating actin filament dynamics at the leading edge of migrating cells. Cofilin is inactivated by phosphorylation at Ser-3 and reactivated by cofilin-phosphatase Slingshot-1L (SSH1L). Little is known of signaling mechanisms of cofilin activation and how this activation is spatially regulated. Here, we show that cofilin-phosphatase activity of SSH1L increases approximately 10-fold by association with actin filaments, which indicates that actin assembly at the leading edge per se triggers local activation of SSH1L and thereby stimulates cofilin-mediated actin turnover in lamellipodia. We also provide evidence that 14-3-3 proteins inhibit SSH1L activity, dependent on the phosphorylation of Ser-937 and Ser-978 of SSH1L. Stimulation of cells with neuregulin-1beta induced Ser-978 dephosphorylation, translocation of SSH1L onto F-actin-rich lamellipodia, and cofilin dephosphorylation. These findings suggest that SSH1L is locally activated by translocation to and association with F-actin in lamellipodia in response to neuregulin-1beta and 14-3-3 proteins negatively regulate SSH1L activity by sequestering it in the cytoplasm."xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200401136"xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200401136"xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.uniprot.org/core/author | "Chiba S."xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.uniprot.org/core/author | "Chiba S."xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.uniprot.org/core/author | "Goto K."xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.uniprot.org/core/author | "Goto K."xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.uniprot.org/core/author | "Iwamatsu A."xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.uniprot.org/core/author | "Iwamatsu A."xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.uniprot.org/core/author | "Mizuno K."xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.uniprot.org/core/author | "Mizuno K."xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.uniprot.org/core/author | "Ohta Y."xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.uniprot.org/core/author | "Ohta Y."xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.uniprot.org/core/author | "Ohashi K."xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.uniprot.org/core/author | "Ohashi K."xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.uniprot.org/core/author | "Kousaka K."xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.uniprot.org/core/author | "Kousaka K."xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.uniprot.org/core/author | "Mori R."xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.uniprot.org/core/author | "Mori R."xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.uniprot.org/core/author | "Nagata-Ohashi K."xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.uniprot.org/core/author | "Nagata-Ohashi K."xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.uniprot.org/core/author | "Nishita M."xsd:string |
| http://purl.uniprot.org/citations/15159416 | http://purl.uniprot.org/core/author | "Nishita M."xsd:string |