| http://purl.uniprot.org/citations/15166220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15166220 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferon (IFN)-lambda 1, -lambda 2, and -lambda 3 are the latest members of the class II cytokine family and were shown to have antiviral activity. Their receptor is composed of two chains, interleukin-28R/likely interleukin or cytokine or receptor 2 (IL-28R/LICR2) and IL-10R beta, and mediates the tyrosine phosphorylation of STAT1, STAT2, STAT3, and STAT5. Here, we show that activation of this receptor by IFN-lambda 1 can also inhibit cell proliferation and induce STAT4 phosphorylation, further extending functional similarities with type I IFNs. We used IL-28R/LICR2-mutated receptors to identify the tyrosines required for STAT activation, as well as antiproliferative and antiviral activities. We found that IFN-lambda 1-induced STAT2 tyrosine phosphorylation is mediated through tyrosines 343 and 517 of the receptor, which showed some similarities with tyrosines from type I IFN receptors involved in STAT2 activation. These two tyrosines were also responsible for antiviral and antiproliferative activities of IFN-lambda 1. By contrast, STAT4 phosphorylation (and to some extent STAT3 activation) was independent from IL-28R/LICR2 tyrosine residues. Taken together, these observations extend the functional similarities between IFN-lambdas and type I IFNs and shed some new light on the mechanisms of activation of STAT2 and STAT4 by these cytokines."xsd:string |
| http://purl.uniprot.org/citations/15166220 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m404789200"xsd:string |
| http://purl.uniprot.org/citations/15166220 | http://purl.uniprot.org/core/author | "Michiels T."xsd:string |
| http://purl.uniprot.org/citations/15166220 | http://purl.uniprot.org/core/author | "Kotenko S.V."xsd:string |
| http://purl.uniprot.org/citations/15166220 | http://purl.uniprot.org/core/author | "Renauld J.C."xsd:string |
| http://purl.uniprot.org/citations/15166220 | http://purl.uniprot.org/core/author | "Dumoutier L."xsd:string |
| http://purl.uniprot.org/citations/15166220 | http://purl.uniprot.org/core/author | "Tounsi A."xsd:string |
| http://purl.uniprot.org/citations/15166220 | http://purl.uniprot.org/core/author | "Sommereyns C."xsd:string |
| http://purl.uniprot.org/citations/15166220 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15166220 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15166220 | http://purl.uniprot.org/core/pages | "32269-32274"xsd:string |
| http://purl.uniprot.org/citations/15166220 | http://purl.uniprot.org/core/title | "Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling."xsd:string |
| http://purl.uniprot.org/citations/15166220 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/15166220 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15166220 |
| http://purl.uniprot.org/citations/15166220 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15166220 |
| http://purl.uniprot.org/uniprot/Q8IU54#attribution-3793C468795571194B17DE5389C29B52 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15166220 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C391-mappedCitation-15166220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15166220 |
| http://purl.uniprot.org/uniprot/#_A4QPA4-mappedCitation-15166220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15166220 |
| http://purl.uniprot.org/uniprot/#_E2JF13-mappedCitation-15166220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15166220 |
| http://purl.uniprot.org/uniprot/#_H2DF04-mappedCitation-15166220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15166220 |
| http://purl.uniprot.org/uniprot/#_Q3MIC3-mappedCitation-15166220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15166220 |
| http://purl.uniprot.org/uniprot/#_G9C945-mappedCitation-15166220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15166220 |
| http://purl.uniprot.org/uniprot/#_Q08334-mappedCitation-15166220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15166220 |
| http://purl.uniprot.org/uniprot/#_Q3ZCM1-mappedCitation-15166220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15166220 |